76 documents found, page 1 of 8
Optical Biosensing Platform for Detection of Antimicrobial Resistance
Oliveira, F.; Nogueira, C.; Catarino, Susana Oliveira; Carvalho, C.Antimicrobial resistance (AMR) is a growing global health challenge, reinforcing the urgent need for rapid and sensitive diagnostic tools. This project aims to develop an optical-electronic system for the detection of specific AMR markers by integrating biosensing elements with an optical signal readout. The system will detect AMR-related targets through a biochemical recognition event that produces an optical ...
After all, Porphyria exists in Portugal! A three-year study
Ferreira, Filipa; Carmona, Célia; Lopes, A.; Ramos, S.; Nogueira, Célia; Pereira, Cristina; Pavão, C.; Oliveira, F.; Pimenta, R.; Brasão, L.Introduction: Porphyrias are a group of eight rare inherited disorders, each caused by a defect in a specific enzymatic step of heme biosynthesis. These disorders are multisystemic, with variable symptoms, and represent a major burden for patients and families, with disabling chronic symptoms scattered with life-threatening acute attacks. There are two main clinical types of porphyria: acute porphyria and cutan...
Combining x-ray real and reciprocal space mapping techniques to explore the epi...
Magalhaes, S.; Cabaco, J. S.; Concepcion, O.; Buca, D.; Stachowicz, M.; Oliveira, F.; Cerqueira, M. F.; Lorenz, K.; Alves, E.In the present work, the importance of determining the strain states of semiconductor compounds with high accuracy is demonstrated. For the matter in question, new software titled LAPAs, the acronym for LAttice PArameters is presented. The lattice parameters as well as the chemical composition of Al1-xInxN and Ge1-xSnx compounds grown on top of GaN- and Ge-buffered c-Al2O3 and (001) oriented Si substrates, resp...
Menthol-based deep eutectic systems as antimicrobial and anti-inflammatory agen...
Oliveira, F.; Silva, Eduardo Alexandre Pereira; Matias, A.; Silva, J. M.; Reis, R. L.; Duarte, A. R. C.Effective antimicrobial treatment has been identified as a serious and unmet medical need. Herein, we present a strategy based on deep eutectic systems (DES) to overcome current limitations, answering the need not only to effectively kill bacterial agents but also to avoid their adhesion and proliferation, which is associated with biofilm formation and have a crucial impact on bacterial virulence. To achieve su...
Confronting Vegard's rule in Ge1-x Sn (x) epilayers: from fundamentals to the e...
Magalhaes, S.; Dias, M.; Nunes, B.; Oliveira, F.; Cerqueira, M. F.; Alves, E.Comprehensive and systematic study challenging the application of Vegard's rule to germanium tin solid solutions grown on germanium buffer layers and 100 silicon substrates is presented. The binary's lattice parameters, composition and respective uncertainties are determined through x-ray diffraction via reciprocal space mapping technique employing newly developed software. The tin content is confirmed by Ruthe...
Bio-tribocorrosion in dental applications
Rocha, L. A. [UNESP]; Oliveira, F.; Cruz, H. V.; Sukotjo, C.; Mathew, M. T.Made available in DSpace on 2022-04-29T07:17:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-01; In the oral cavity, materials (including our natural teeth) are exposed to a complex environment, which results in simultaneous mechanical, electrochemical, and microbiological solicitations. Therefore, bio-tribocorrosion is an important cause of degradation of dental materials leading to functional and...
Cylindrospermopsin and glyphosate accumulation in lettuce (Lactuca sativa) simu...
Sengupta, S.; Freitas, Marisa; Pinto, Edgar; Ferreira, I.; Oliveira, F.; Azevedo, J.; Prieto, A.; Diez-Quijada, L.; Jos, A.; Cameán, A.M.; Campos, A.In nature, the simultaneous occurrence of multiple emergent contaminants such as cyanotoxins (e.g., cylindrospermopsin (CYN)) and herbicides (e.g., glyphosate (GLY)), is highly expectable and it can be anticipated, mainly in the aquatic and terrestrial environments. The use of contaminated water for irrigation can be hazardous to the agricultural sector and some studies have reported that, individually, these c...
Effects of cylindrospermopsin and glyphosate at environmentally relevant concen...
Priya, V.; Freitas, Marisa; Pinto, Edgar; Almeida, A.; Oliveira, F.; Azevedo, J.; Campos, A.; Sudhakaran, R.; Vasconcelos, V.Natural toxins produced by freshwater cyanobacteria, such as cylindrospermopsin (CYN), have been regarded as an emergent environmental threat. Cyanotoxins can be applied directly to soil by using contaminated water for agricultural irrigation. Despite the risks for food safety, the impact of cyanotoxins in agriculture is not yet fully understood. Furthermore, in soil-plant system the simultaneous occurrence of ...
Optimal design of THEDES based on Perillyl Alcohol and Ibuprofen
Silva, Eduardo Alexandre Pereira; Oliveira, F.; Silva, Joana M.; Matias, A.; Reis, R. L.; Duarte, Ana Rita C.Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratio...
Chlorosphaerolactylates A−D: Natural lactylates of chlorinated fatty acids isol...
Gutiérrez-Del-Río, I.; de Fraissinette, N.B.; Castelo-Branco, R.; Oliveira, F.; Morais, J.; Redondo-Blanco, S.; Villar, C.J.; José Iglesias, M.Four natural lactylates of chlorinated fatty acids, chlorosphaerolactylates A−D (1−4), were isolated from the methanolic extract of the cyanobacterium Sphaerospermopsis sp. LEGE 00249 through a combination of bioassay-guided and MS-guided approaches. Compounds 1−4 are esters of (mono-, di-, or tri)chlorinated lauric acid and lactic acid, whose structures were assigned on the basis of spectrometric and spectrosc...