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N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent ...
Okamura, Adriana Mary Nunes Costa; Gomes, Patrícia Xavier L.; Oliveira, Gersilene V. de; Araújo, Fernanda Yvelize R. de; Tomaz, Viviane S.Kindling We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To ...
Date: 2016
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Origin: Oasisbr