2 documents found, page 1 of 1
A multicentric evaluation of the recombinant Leishmania infantum antigen-based ...
Fraga, Deborah Bittencourt Mothé; Silva, Edimilson Domingos da; Pacheco, Luciano Vasconcellos; Borja, Lairton Souza; Oliveira, Isaac Queiroz deBackground: Visceral leishmaniasis (VL) is a serious public health challenge in Brazil and dogs are considered to be the main urban reservoir of the causative agent. The culling of animals to control VL in some countries makes the accurate diagnosis of canine VL (CVL) essential. Recombinant antigens rLci1A and rLci2B were selected from a cDNA library of Leishmania infantum amastigotes due to their strong potent...
Multi-antigen print immunoassay (MAPIA)-based evaluation of novel recombinant L...
Oliveira, Isaac Queiroz de; Silva, Rodrigo Araujo; Sucupira, Michel Vergne; Silva, Edmilson Domingos da; Reis, Alexandre BarbosaBackground: Domestic dogs are the principal reservoir hosts of Leishmania infantum in regions where visceral leishmaniasis (VL) is endemic. Although serologic methods are frequently used for the screening of infected dogs, antibody-based tests require further assessment, due to lack of sensitivity and specificity. In this study, we employed a multi-antigen printing immunoassay (MAPIA) to compare the antibody re...