We would like to thank Pereira (2015) for his interest in our work and appreciate the opportunity to clarify some aspects of the Rodrigues et al. (2015) study. Here we dispute several fundamental assertions made in the discussion of our original paper. (1) Pereira (2015) states, based on the U–Pb detrital zircon data of Pereira et al. (2012a, 2014), that the turbidites of the Mértola (late Visean) and the Mira ...
Cartografia geológica realizada pelo Laboratório Nacional de Energia e Geologia (LNEG) acompanhada por estudos palinostratigráficos na região de Malhadinha, NE de Alvares, localizada no setor WNW da Faixa Piritosa Ibérica (FPI), concelho de Mértola, possibilitaram o conhecimento de detalhe da estratigrafia local. Apresentam-se as idades obtidas por palinologia para as formações Barranco do Homem e Filito-Quartz...
U–Pb detrital zircon data from the Baixo Alentejo Flysch Group in the South Portuguese Zone show significant age differences between formations. The Visean Mértola Formation and Serpukhovian to early Bashkirian Mira Formation are dominated by zircons in the 316–388Ma age range, whereas the late Bashkirian to late Moscovian Brejeira Formation is dominated by zircons with an age range of 498–687Ma. Detrital zirco...
Foram obtidas idades U-Pb através de ablação a lazer de zircões detríticos das formações do Grupo do Flysch do Baixo Alentejo. As idades obtidas sugerem uma proveniência sedimentar, no caso das formações de Mértola e Mira, com o envolvimento de uma componente detrítica intrabasinal (Zona Sul Portuguesa) e de áreas fontes associadas ao bordo sul da Zona da Ossa Morena. No caso da Formação de Brejeira as idades s...
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Human articular cartilage functions under a wide range of mechanical loads in synovial joints, where hydrostatic pressure (HP) is the prevalent actuating force. We hypothesized that the formation of engineered cartilage can be augmented by applying such physiologic stimuli to chondrogenic cells or stem cells, cultured in hydrogels, using custom-designed HP bioreactors. To test this hypothesis, we investigated t...
Spinal cord injury (SCI) represents a significant health and social problem, and therefore it is vital to develop novel strategies that can specifically target it. In this context, the objective of the present work was to develop a new range of three-dimensional (3D) tubular structures aimed at inducing the regeneration within SCI sites. Up to six different 3D tubular structures were initially developed by rapi...
Low back pain is one of the most reported medical conditions associated to intervertebral disc (IVD) degeneration. Nucleus pulposus (NP) is often regarded as the structure where intervertebral disc degeneration begins. Gellan gum-based (GG) hydrogels for acellular and cellular tissue engineering strategies have been developed for finding applications as NP substitutes. The innovative strategy is based on the re...
Tissue engineering was proposed approximately 15 years ago as an alternative and innovative way to address tissue regeneration problems. During the development of this field, researchers have proposed a variety of ways of looking into the regeneration and engineering of tissues, using different types of materials coupled with a wide range of cells and bioactive agents. This trilogy is commonly considered the ba...
Intervertebral disc (IVD) degeneration is a challenging clinical problem that urgently demands viable nucleus pulposus (NP) implant materials. The best suited biomaterial for NP regeneration has yet to be identified, but it is believed that biodegradable hydrogel-based materials are promising candidates. In this work, we have developed ionic- and photo-crosslinked methacrylated gellan gum (GG–MA) hydrogels to b...