6 documents found, page 1 of 1
Phage Display Identified Peptide with Selectivity for Human Osteoarthritic Chon...
Martins, IM; Canadas, RF; Pereira, H; Azeredo, J; Reis, RL; Oliveira, JM; Azevedo, HSOsteoarthritis (OA) is one of the most common joint disorders in western populations, affecting millions of people worldwide and with a rising incidence as life expectancy continues to increase. Current therapies for OA management fail to halt the progressive degradation of articular cartilage, urging the need for more effective therapies to improve function and enhance quality of life. Through phage display te...
Determination of the absolute configuration of bioactive indole-containing pyra...
Long, S; Furlani, IL; Oliveira, JM; Resende, DISP; Silva, AMS; Gales, L; Pereira, JA; Kijjoa, A; Cass, QB; Oliveira, RV; Sousa, E; Pinto, MMMIn recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, and elimination (ADME) properties. To perform metabolic studies, the synthesis of the naturally occurring quinazolinone, fiscalin B (1), and its chloro derivative, 4-((1H...
In vitro and in vivo performance of methacrylated gellan gum hydrogel formulati...
Vilela, CA; Correia, C; Morais, AS; Santos, TC; Gertrudes, AC; Moreira, ES; Frias, AM; Learmonth, DA; Oliveira, P; Oliveira, JM; Sousa, RAMethacrylated gellan gum (GGMA) formulation is proposed as a second‐generation hydrogel for controlled delivery of cartilage‐forming cells into focal chondral lesions, allowing immediate in situ retention of cells and 3D filling of lesion volume, such approach deemed compatible with an arthroscopic procedure. Formulation optimization was carried out in vitro using chondrocytes and adipose mesenchymal stromal/st...
Osteochondral transplantation using autografts from the upper tibio-fibular joi...
Espregueira-Mendes, J; Pereira, H; Sevivas, N; Varanda, P; Vieira da Silva, M; Monteiro, A; Oliveira, JM; Reis, RLPURPOSE: Treatment of large cartilage lesions of the knee in weight-bearing areas is still a controversy and challenging topic. Autologous osteochondral mosaicplasty has proven to be a valid option for treatment but donor site morbidity with most frequently used autografts remains a source of concern. This study aims to assess clinical results and safety profile of autologous osteochondral graft from the upper ...
Assessment of rotatory laxity in anterior cruciate ligament-deficient knees usi...
Espregueira-Mendes, J; Pereira, H; Sevivas, N; Passos, C; Vasconcelos, JC; Monteiro, A; Oliveira, JM; Reis, RLPURPOSE: Objective evaluation of both antero-posterior translation and rotatory laxity of the knee remains a target to be accomplished. This is true for both preoperative planning and postoperative assessment of different ACL reconstruction emerging techniques. The ideal measurement tool should be simple, accurate and reproducible, while enabling to assess both ‘‘anatomy’’ and ‘‘function’’ during the same exami...
Coronary artery bypass surgery with intermittent aortic cross-clamping
Antunes, MJ; Bernardo, JE; Oliveira, JM; Fernandes, LE; Andrade, CMDespite the generally accepted use of cardioplegia for myocardial protection during cardiac revascularization and other operations, non-cardioplegic methods have been used by many surgeons throughout the world. We have prospectively studied 229 patients consecutively subjected to isolated coronary artery bypass surgery from March 1990 to February 1991 by a single surgeon who used intermittent aortic cross-clamp...