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Insights into bioengineering approaches for aging bone regeneration: strategies...
Xiao, Lan; Gao, Wendong; Wu, Jinfu; Erezuma, Itsasne; Dolatshahi-Pirouz, Alireza; Silva-Correia, Joana; Zhou, Yinghong; Sun, Antonia RujiaThe global accumulation of ageing population is a serious problem causing significant health and social burdens. Especially, aging results in reduced bone regeneration potential and increased risk of morbidities and mortality, which calls the urgent need for advanced therapeutic approaches to improve bone regeneration in the aged patients. The aging associated poor bone regeneration capacity can be attributed t...
In vitro bone tissue engineering strategies: the relevance of cells and culturi...
Bastos, Ana Raquel Fernandes; Maia, F. Raquel; Oliveira, Joaquim M.; Reis, R. L.; Correlo, V. M.The most recent advances in bone tissue engineering (BTE) approaches step forward in the field of three-dimensional (3D) tissue models, enabling the development of more realistic tools to study bone disorders, such as osteoporosis. BTE field aims to mimic native bone tissue more truthfully, providing an appropriate environment for tissue regeneration and repair through the combination of 3D porous scaffolds, sp...
Gellan gum-based bioink for bioprinting of a mechanically mimetic 3D in vitro l...
Kohori, N. A.; Cengiz, I. F.; Carvalho, Mariana; Silva-Correia, J.; Pires, R. A.; Riccardi, C.; Pereira, L. C.; Reis, R. L.; Oliveira, Joaquim M.The liver is vital for the human body's metabolism, making the development of more predictable and reproducible pathophysiological-relevant three-dimensional (3D) liver models crucial for studying the accumulation of xenobiotics and associated liver diseases. In this work, we describe the development of a bioink comprising 0.2% w/v TayaGel® HA (high acyl gellan gum) and 1.2% w/v Gelzan™ CM (low acyl gellan gum)...
3D-printed cell-instructive scaffolds based on Chondrosia reniformis collagen a...
Rocha, Miguel Soares; Marques, Ana Catarina Fernandes; Pina, Sandra Cristina Almeida; Oliveira, Joaquim M.; Reis, R. L.; Silva, Tiago H.Bone defects pose a global concern due to their high prevalence. Despite the significant advances in the development of novel therapies and sustainable biomaterial solutions, these still do not perfectly address the clinical needs, in particular, the paradigm shift of personalized treatments. In this sense, marine-origin materials allied to three-dimensional (3D) printing are arising as a feasible alternative t...
Highly sensitive ratiometric fluorescent fiber matrices for oxygen sensing with...
Grasso, Giuliana; Onesto, Valentina; Forciniti, Stefania; D’Amone, Eliana; Colella, Francesco; Pierantoni, Lara; Famà, Valeria; Gigli, GiuseppeOxygen (O2 )-sensing matrices are promising tools for the live monitoring of extracellular O 2 consumption levels in long-term cell cultures. In this study, ratiometric O2 -sensing membranes were prepared by electrospinning, an easy, low-cost, scalable, and robust method for fabricating nanofibers. Poly(ε-caprolactone) and poly(dimethyl)siloxane polymers were blended with tris(4,7-diphenyl-1,10-phenanthroline)...
Advancing diagnostics and disease modeling: current concepts in biofabrication ...
Casanova, César R.; Casanova, Marta Alexandra Rodrigues; Reis, R. L.; Oliveira, Joaquim M.Soft microfluidic systems play a pivotal role in personalized medicine, particularly in in vitro diagnostics tools and disease modeling. These systems offer unprecedented precision and versatility, enabling the creation of intricate three-dimensional (3D) tissue models that can closely emulate both physiological and pathophysiological conditions. By leveraging innova- tive biomaterials and bioinks, soft microfl...
Evaluation of novel dendrimer-gold complex nanoparticles for theranostic applic...
Milivojevic, Nevena; Carvalho, Mariana Rodrigues; Caballero, David; Radisavljevic, Snezana; Radoicic, Marija; Živanović, Marko; Kundu, Subhas CAim: Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment. Methods: The authors developed two novel dendrimerâ gold (Au) complex-based nanoparticles using twodifferent synthesis routes: complexation method (formulation A) and precipitation method (formu...
Characterization of iron oxide nanotubes obtained by anodic oxidation for biome...
Rangel, Rita de Cássia Reis; Rangel, André Luiz Reis; Silva, Kerolene Barboza da; Escada, Ana Lúcia do Amaral; Chaves, Javier Andres MunozTo improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 Vâ 30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm)....
3D-printed variable stiffness tissue scaffolds for potential meniscus repair
Murphy, Caroline A.; Serafin, Aleksandra; Cengiz, I. F.; Reis, R. L.; Oliveira, Joaquim M.; Collins, Maurice N.The treatment of meniscus injuries has recently been facing a paradigm shift toward the field of tissue engineering (TE), with the aim of regenerating damaged and diseased menisci. In this work, bovine meniscus was characterized, and the regionally-dependent mechanical properties analysed. It was established that both the collagen structure and glycosaminoglycans (GAG) content play a critical synergetic role in...
Extraction and purification of biopolymers from marine origin sources envisagin...
Carvalho, Duarte Nuno; Gonçalves, João N. C.; Sousa, Rita Alexandra Oliveira; Reis, R. L.; Oliveira, Joaquim M.; Silva, Tiago H.Biopolymers are a versatile and diverse class of materials that has won high interest due to their potential application in several sectors of the economy, such as cosmetics, medical materials/devices, and food additives. In the last years, the search for these compounds has explored a wider range of marine organisms that have proven to be a great alternative to mammal sources for these applications and benefit...