18 documents found, page 1 of 2
SARS-CoV-2 immunization in academic community: vaccination schemes efficiency
Almeida, Ana; Oliveira, Ketlyn; Ribeiro, EdnaBackground: Severe acute respiratory syndrome coronavirus 2 immunoglobulin G (SARS-CoV-2-IgG) antibodies have been widely used to assist clinical diagnosis and occupational exposure risks. Objectives: This study aimed to estimate SARS-CoV-2 IgG levels acquired due to different vaccination schemes. Materials and methods: A retrospective study was performed on volunteers from the Instituto Politécnico de Lisboa. ...
Towards an integrated approach on occupational health to tackle COVID-19 pandemic
Ribeiro, Edna; Oliveira, Ketlyn; Dias, Marta; Gomes, Bianca; Pimenta, Raquel; Delgadinho, Mariana; Ginete, Catarina; Abreu, RenatoBackground: Serological screening is crucial for the prevention of infection, ensuring the maintenance of the worker’s health, and thus promoting occupational health. It was reported that SARS-CoV-2 can survive in aerosols and on dry surfaces for several days to weeks. Objectives: We aimed to apply an integrated approach to Occupational Health to tackle the COVID-19 pandemic. Materials and methods: We performed...
SARS-CoV-2 immunization index in the academic community: a retrospective post-v...
Oliveira, Ketlyn; Almeida, Ana; Silva, Carina; Brito, Miguel; Ribeiro, EdnaBackground/Objectives: The COVID-19 pandemic has revolutionized vaccine production and compelled a massive global vaccination campaign. This study aimed to estimate the positivity and levels of SARS-CoV-2 IgG antibodies acquired due to vaccination and infection in the academic population of a Portuguese university. Methods: Blood samples were collected and analyzed using the ELISA methodology, and statistical a...
Analysis of the biological effect of Carica papaya leaf extracts on the viabili...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, AnitaBackground – Sickle cell disease (SCD) is a genetic blood disorder caused by mutations in the β-globin gene that affects the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of fetal hemoglobin (HbF) through compounds such as hydroxyurea (HU), is one of the currently available treatments, however, their safety concerns and expen...
Exposure to metals in the e-waste management industry
Martins, Carla; Ribeiro, Edna; Oliveira, Ketlyn; Viegas, SusanaObjective: The burden of disease associated with occupational exposure is ~6%. The recent EU circular economy policy, where the recycling of e-waste is included, is expected to increase the waste management/recycling sector. The e-waste stream contains a broad range of chemicals namely metals. Human biomonitoring by measurement of specific biomarkers in body fluids is considered an effective method of exposure ...
DNA methyltransferase expression (DNMT1, DNMT3a and DNMT3b) as a potential biom...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Varandas, Teresa; Nascimento, João; Henriques, José; Dutra-Medeiros, Marco; Delgadinho, MarianaPurpose: DNA methylation is involved in Diabetic Retinopathy progression showing a metabolic memory mechanism. However, the association of DNA methyltransferase with diabetic macular edema is still unknown. We aimed to describe the differences in DNA methyltransferase gene expression in patients with different diabetic macular edema responses. Methods: A total of 27 diabetic patients, aged 59-90 years, were pro...
Effects of Quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelHemoglobinopathies are a group of inherited blood disorders that primarily affect red blood cells. The most common type is known as sickle cell anemia (SCA). It is characterized by mutations in the HBB gene, which encodes the β-subunit of human hemoglobin, giving rise to hemoglobin S (HbS). When deoxygenated, HbS polymerizes in the red blood cell, giving it a sickle shape and making it rigid and fragile. Fetal ...
Effects of quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle Cell anemia (SCA) is a hereditary hemoglobinopathy with the formation of hemoglobin S, associated with severe health outcomes. Currently, induction of fetal hemoglobin (HbF) is one of the most promising therapeutic strategies. Here we aimed to assess the potential of the natural compound Quercetin, in transcriptional expression of globin and HbF regulatory/silencing genes. In this study, the K562 cell li...
Análise do efeito biológico de extratos de folhas de Carica papaya na viabilida...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, Anita Q.Introdução – A anemia falciforme é uma doença monogénica causada por mutações no gene da β-globina que afeta a estrutura da hemoglobina, sendo associada a diversas complicações clínicas com elevadas taxas de morbilidade e mortalidade. A reativação farmacológica da hemoglobina fetal (HbF) por compostos como a hidroxiureia (HU) é um dos tratamentos atualmente disponíveis; contudo, o seu perfil de segurança e o el...
Effects of methanolic and aqueous Carica Papaya leaf extracts in transcriptiona...
Jacques, Filipa; Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle cell disease (SCD) is a genetic blood disorder caused by mutations in β-globin gene that affect the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of Fetal Hemoglobin (HbF) through compounds such as Hydroxyurea (HU), is one of the available treatments, however, their safety concerns and expensive cost in low- and middle...