Made available in DSpace on 2022-04-29T08:36:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; Cryptococcosis is associated with high rates of morbidity and mortality, especially in AIDS patients. Its treatment is carried out by combining amphotericin B and azoles or flucytosine, which causes unavoidable toxicity issues in the host. Thus, the urgency in obtaining new antifungals drives the search...
Made available in DSpace on 2021-06-25T10:37:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-14; The oral cavity is a highly diverse microbial environment in which microorganisms interact with each other, growing as biofilms on biotic and abiotic surfaces. Understanding the interaction among oral microbiota counterparts is pivotal for clarifying the pathogenesis of oral diseases. Candida spp. is on...
Made available in DSpace on 2021-06-25T10:51:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-22; Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins, acting as essential regulators of diverse constitutive metabolic processes. The Hsp60 of the dimorphic fungal Histoplasma capsulatum is the major surface adhesin to mammalian macrophages and studies of ...
Made available in DSpace on 2021-06-25T11:10:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and requires prolonged treatment; therefore, new therapeutic approaches are necessary. I...