20 documents found, page 1 of 2
Signature cytokine-associated transcriptome analysis of effector γδ T cells ide...
Inácio, Daniel; Amado, Tiago; Pamplona, Ana; Sobral, Daniel; Cunha, Carolina; Santos, Rita F.; Oliveira, Liliana; Rouquié, Nelly; Carmo, Alexandre M.γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) are generated in the mouse thymus, but the molecular regulators of their peripheral functions are not fully characterized. Here we established an Il17a-GFP:Ifng-YFP double-reporter mouse strain to analyze at unprecedented depth the transcriptomes of pure γδ17 cell versus γδIFN cell populations from peripheral lymph nodes. Wit...
Contributos para o estudo dos construtores navais nas ribeiras do Estado da Índ...
Oliveira, LilianaIndian shipyards were developed to respond to the challenges of the empire’s expansion. Gradually, these spaces took on two dimensions: their activity was intended to satisfy the needs of the Cape route, and to support another commercial circuit, the intra-Asian. To guarantee the functionality of this entire system, there was a professional group in each riverside responsible for the tasks of shipbuilding and s...
Signature cytokine-associated transcriptome analysis of effector γδ T cells ide...
Inácio, Daniel; Amado, Tiago; Pamplona, Ana; Sobral, Daniel; Cunha, Carolina; Santos, Rita F.; Oliveira, Liliana; Rouquié, Nelly; Carmo, Alexandre M.γδ T cells producing either interleukin-17A (γδ cells) or interferon-γ (γδ cells) are generated in the mouse thymus, but the molecular regulators of their peripheral functions are not fully characterized. Here we established an Il17a-GFP:Ifng-YFP double-reporter mouse strain to analyze at unprecedented depth the transcriptomes of pure γδ cell versus γδ cell populations from peripheral lymph nodes. Within a very...
Development of bioluminescent Group B streptococcal strains for longitudinal in...
Lorga, Inês; Geraldo, Rafaela; Soares, Joana; Oliveira, Liliana; Firon, Arnaud; Andrade, Elva BonifácioGroup B Streptococcus (GBS) remains the leading bacterial cause of invasive neonatal disease, resulting in substantial morbidity and mortality. New therapeutic approaches beyond antibacterial treatment to prevent neonatal disease outcomes are urgent. One significant limitation in studying GBS disease and progression is the lack of non-invasive technologies for longitudinal studies. Here, we develop and compare ...
Development of bioluminescent Group B streptococcal strains for longitudinal in...
Lorga, Inês; Geraldo, Rafaela; Soares, Joana; Oliveira, Liliana; Firon, Arnaud; Bonifácio Andrade, ElvaGroup B Streptococcus (GBS) remains the leading bacterial cause of invasive neonatal disease, resulting in substantial morbidity and mortality. New therapeutic approaches beyond antibacterial treatment to prevent neonatal disease outcomes are urgent. One significant limitation in studying GBS disease and progression is the lack of non-invasive technologies for longitudinal studies. Here, we develop and compare ...
Cancer searching after unprovoked Thromboembolism – still a clinical controversy
Mendonça, Joana; Campos, Ana Luísa; Barbosa Martins, João; Barbosa, Ana; Rolo, Ana Sofia; Oliveira, Liliana; Carvalho, Carolina; Faustino, IldaUnprovoked Venous thromboembolism (VTE) may be the first sign of an occult cancer. To identify VTE patients at increased risk of cancer and that would have grater benefit from an extensive screening, the RIETE prediction score was developed. We designed an unicentric prospective trial at Senhora da Oliveira Hospital to evaluate the RIETE score performance in identifying the patients at a high-risk of a cancer d...
Seismic microzonation studies for Lisbon
Oliveira, LilianaLisbon has a moderate to high seismic risk due to its seismicity, socioeconomic importance and dense urbanisation. Its complex geomorphological structure may aggravate soil amplification and cause higher structural damage. The present work improves the soil dynamic characterisation and seismic site response assessment in Lisbon. Based on a multidisciplinary dataset composed of surface geology, a geotechnical da...
CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effe...
Cardoso, Marcos S.; Gonçalves, Rute; Oliveira, Liliana; Silvério, Diogo; Téllez, Erica; Paul, Tony; Sarrias, Maria Rosa; Carmo, Alexandre M.Tuberculosis (TB) alone caused over a billion deaths in the last 200 years, making it one of the deadliest diseases to humankind. Understanding the immune mechanisms underlying protection or pathology in TB is key to uncover the much needed innovative approaches to tackle TB. The scavenger receptor cysteine-rich molecule CD5 antigen-like (CD5L) has been associated with TB, but whether and how CD5L shapes the im...
How climate scientists and communication professionals view public engagement w...
Oliveira, Liliana; Carvalho, AnabelaIntroductionThis article examines understandings of public engagement in science by scientists and communicators in four universities in Portugal and Spain. MethodsBased on mixed-methods research, we present an integrative analysis of practices and perceptions of climate change scientists and communication professionals, and identify critical barriers for them to further public engagement. ResultsMore similarit...
Inteligência artificial, Big Data e decisão dos gestores: Desafios e oportunida...
Oliveira, Liliana; Augusto, Mário; Torres, PedroA inteligência artificial (IA) e o big data anunciam uma mudança de paradigma na tomada de decisão. Apesar do crescente interesse académico acerca destes temas emergentes, a investigação acerca de como eles se entrecruzam com a tomada de decisões estratégicas e, em particular, com a forma como os gestores tomam decisões, é praticamente inexistente. Para obter uma visão geral da investigação sobre estes temas, d...