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Cardiovascular responses to L-glutamate microinjection into the NTS are abrogat...
Granato, Álisson Silva; Gomes, Paula Magalhães; Sá, Renato Willian Martins; Borges, Gabriel Silva Marques; Alzamora, Andréia CarvalhoRedox imbalance in regions of the CNS controlling blood pressure is increasingly recognized as a leading factor for hypertension. Nucleus tractus solitarius (NTS) of the dorsomedial medulla is the main region receiving excitatory visceral sensory inputs that modulate autonomic efferent drive to the cardiovascular system. This study sought to determine the capacity of reduced glutathione, a major bioactive antio...
Mecanismos gabaérgicos e opióides do núcleo parabraquial lateral envolvidos no ...
Oliveira, Lisandra Brandino deUniversidade Federal de Minas Gerais; The lateral parabrachial nucleus (LPBN) is a pontine structure located in the dorsal portion of the cerebelar superior peduncle. LPBN receives afferent projections from the area postrema (AP) and the medial portion of the nucleus of tractus solitarius (mNTS) and connects to prosencephalic areas related to hidroelectrolytic control, such as specific nuclei of the hypothalamu...
Efeitos da injeção de moxonidina no controle da ingestão de sódio e regulação c...
Oliveira, Lisandra Brandino deUniversidade Federal de Minas Gerais; Deficit of water and sodium in the body is detected by receptors located in different parts of the body. These receptors or hormones signalize to specific areas in the brain that control renal responses and water and sodium intake. Among these areas are: organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), anteroventral third ventricle (AV3V) region,...
Gabaergic and opioid receptors mediate the facilitation of NaCl intake induced ...
Andrade, C. A. F.; Oliveira, Lisandra Brandino de; Franzé, Gláucia Maria Fabrício de Andrade; Luca Junior, L. A. de; Colombari, Débora Simões de AlmeidaAlpha2-adrenergic, gabaergic or opioidergic activation in the lateral parabrachial nucleus (LPBN) increases sodium intake. In the present study, we investigated the effects of single or combined block-ade of opioidergic and gabaergic receptors in the LPBN on the increase of 0.3 M NaCl intake induced by _2-adrenoceptor activation in the LPBN. Male Holtzman rats (n = 5–9/group) with cannulas implanted bilaterally...
Opioid activation in the lateral parabrachial nucleus induces hypertonic sodium...
Oliveira, Lisandra Brandino de; Luca Junior, L. A. de; Menani, José VanderleiOpioid mechanisms are involved in the control of water and NaCl intake and opioid receptors are present in the lateral parabrachial nucleus (LPBN), a site of important inhibitory mechanisms related to the control of sodium appetite. Therefore, in the present study we investigated the effects of opioid receptor activation in the LPBN on 0.3 M NaCl and water intake in rats. Male Holtzman rats with stainless steel...
Sodium intake by hyperosmotic rats treated with a GABAA receptor agonist into t...
Kimura, Everton Heidi; Oliveira, Lisandra Brandino de; Colombari, Débora Simões de Almeida; Luca Junior, L. A. de; Menani, José VanderleiInhibitory mechanisms in the lateral parabrachial nucleus (LPBN) and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. Besides increasing fluid depletion-induced sodium intake, the activation of GABAA receptors with muscimol into the LPBN also induces ingestion of 0.3 M NaCl in normonatremic, euhydrated rats. It has been suggested that inhibitory mechanisms activated by osmot...
Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chlori...
Kimura, Everton Heidi; Oliveira, Lisandra Brandino de; Menani, José Vanderlei; Callera, João CarlosBackground: Activation of GABAB receptors with baclofen into the lateral parabrachial nucleus (LPBN) induces ingestion of water and 0.3 M NaCl in fluid replete rats. However, up to now, no study has investigated the effects of baclofen injected alone or combined with GABAB receptor antagonist into the LPBN on water and 0.3 M NaCl intake in rats with increased plasma osmolarity (rats treated with an intragastric...
Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chlori...
Oliveira, Lisandra Brandino de; Kimura, Everton Heidi; Callera, João Carlos; Luca Junior, L. A. de; Colombari, Débora Simões de AlmeidaGABAA and GABAB receptors are present in the lateral parabrachial nucleus (LPBN), a pontine area involved with inhibitory mechanisms related to the control of sodium appetite. Activation of GABAA receptors in the LPBN induces strong ingestion of 0.3 M sodium chloride (NaCl) in normonatremic and euhydrated rats. In the present study, we investigated the effects of the GABAB receptor agonist baclofen, injected al...
GABAergic mechanisms of the lateral parabrachial nucleus on sodium appetite.
Oliveira, Lisandra Brandino de; Callera, João Carlos; Luca Junior, L. A. de; Colombari, Débora Simões de Almeida; Menani, José VanderleiGABAergic activation in the lateral parabrachial nucleus (LPBN) induces sodium and water intake in satiated and normovolemic rats. In the present study we investigated the effects of GABAA receptor activation in the LPBN on 0.3M NaCl, water, 2% sucrose and food intake in rats submitted to sodium depletion (treatment with the diuretic furosemide subcutaneously + sodium deficient food for 24 h), 24 h food depriva...
Chemoreflex control of the cardiovascular system remains altered after recovery...
Sá, Renato Willian Martins; Borges, Gabriel Silva Marques; Chianca Júnior, Deoclécio Alves; Oliveira, Lisandra Brandino de; Cardoso, Leonardo MáximoThis study aimed to evaluate the cardiovascular component of the arterial chemoreflex in rats recovered from low protein diet. Male Fischer rats were randomly divided into control and recovered (R-PR) groups after weaning. R-PR rats were fed with low protein diet for 35 days and recovered under normal protein diet for 70 days. Control rats received normal protein diet for 105 days. Arterial chemoreflexwas elici...