49 documents found, page 1 of 5
Alzheimer’s detection through structural MRI texture analysis
Oliveira, M. J.; Ribeiro, P.; Rodrigues, P. M.Introduction: Alzheimer’s Disease (AD) is the most common cause of dementia. It affects mostly the elderly and is directly impacted by the observed growth of life expectancy. AD manifests as a chronic and progressive neurodegenerative disease, gradually deteriorating memory and cognitive abilities, and diminishing day-to-day quality of life. As the global population ages, understanding and addressing the challe...
Nature pleated surfaces
Oliveira, M. J.; Osório, F.This paper presents a concept design methodology that intends to enable us-ers to design a self-supporting structure based on the terrestrial plants’ bio-logical properties and on origami geometric principles that was tested on an eight-hour workshop at eCAADe/SiGraDi’2019 in Oporto. Focusing on rigid and flat-foldable origami surfaces the methodology invites its users to deal with several architectural aims, c...
Proof of Concept (PoC) 1.0—Implementing a bioshading system design method
Oliveira, M. J.; Rato, V.; Leitão, C.Nature provides a remarkable database of possible adaptation strategies that can be implemented in biomimetic design of shading systems. However, at this moment, successful design methods are conditioned to a limited knowledge and ability to emulate nature’s strategies to meet corresponding functional needs. The implementation of biomimetic processes has some major challenges: (1) the search and selection among...
Bioshading system design method (BSDM)
Oliveira, M. J.; Rato, V.; Leitão, C.Bioshading System Design Method (BSDM) is an architectural problem-based method that uses Nature events as inspirational sources to develop and create performative and design solutions for responsive shading systems. The design method is supported by a circular relationship between three main domains: Architecture, Nature, and Artifact. The "Architecture" domain corresponds to the "Definition" process of the ar...
Bioshading system design methodology - PoC 1.0
Oliveira, M. J.; Rato, V.; Leitão, C.Nature provides a remarkable database of possible adaptation strategies that can be implemented in biomimetic design of shading systems. However, at this moment, successful design methods are conditioned to a limited knowledge and ability to emulate nature’s strategies to meet corresponding functional needs. The implementation of biomimetic processes has as some major challenges: 1- the search and selection amo...
Automation and optimization of in-situ assessment of wall thermal transmittance...
Bienvenido-Huertas, David; Rubio-Bellido, Carlos; Luis Perez-Ordonez, Juan; Oliveira, M. J.Reducing energy consumption and greenhouse gases emissions is among the main challenges of building sector. It is therefore crucial to know the characteristics of envelopes. There are experimental methods to determine thermal transmittance, but limitations are presented. By using techniques of artificial intelligence, this article solves the limitations of current methods by predicting correctly the thermal tra...
Strategies to mitigate shrinkage in an intermediate strength self-compacting co...
Oliveira, M. J.; Bettencourt Ribeiro, Antonio; Branco, Fernando G.Self-compacting concrete (SCC) is a concrete that does not require vibration for casting and consolidation. It is able to flow under its own weight, completely filling the formwork and achieving full consolidation, even in the presence of congested reinforcement. SCC possesses special technical features and properties that recommend its application in a considerable amount of applications. Nevertheless, an inad...
KINE[SIS]TEM´17: a methodological process for a Nature-Based Design
Oliveira, M. J.; Rato, V. M.; Leitão, C.Architecture is the mediator between the Environment and Humans. Nature maximal performance and minimal resources creations are Humanity inspiration that led us to exceed structural, material, mechanisms, tools, systems and methods boundaries (Oxman, 2010).Nature are the Architect of the most reliable and sustainable systems. Looking into Nature's lessons, this paper presents a Nature-based design methodology c...
KINE[SIS]TEM’17 From Nature to Architectural Matter International Conference
Oliveira, M. J.; Rato, V.; Leitão, C.With nature as a starting point, KINESISTEM’17 was the first International Conference held in Portugal aiming to share and debate research and design work related to the integration of natural geometries, mechanics and systems fundamentals applied to the scale, function and aesthetics of architecture. Four prominent guest keynote speakers set the pace of the conference: Manuel Kretzer, Alex Haw, Bob Sheil and A...
Influence of KRAS activation in the colorectal cancer immunosurveillance escape
Machado, Ana Luísa; Mendonça, S.; Carvalho, P. Dias; Martins, F.; Oliveira, M. J.; Velho, S.The immune system as a host defense system watches the cell growth and division, eliminating cells with antigens different from those present in healthy cells. However, some transformed cells have the capacity, through various mechanisms, to escape the immune system. Genomic instability and some mutations are pointed as possible mechanisms supporting the immunosurveillance escape, as is the case of KRAS mutatio...