39 documents found, page 1 of 4
Malignancy risk of thyroid nodules: quality assessment of the thyroid ultrasoun...
Raposo, L; Freitas, C; Martins, R; Saraiva, C; Manita, I; Oliveira, MJ; Marques, AP; Marques, B; Rocha, G; Martins, T; Azevedo, T; Rodrigues, FBackground Thyroid nodules are a challenge in clinical practice and thyroid ultrasonography is essential for assessing the risk of malignancy. The use of ultrasound-based malignancy risk classification systems has been recommended by several scientific societies but radiologist’s adherence to these guidelines may vary. The authors aimed to analyze the quality of the information provided by the thyroid ultrasoun...
Pro-inflammatory polarization and colorectal cancer modulate alternative and in...
Wilton, J; Mendonça, FL; Pereira-Castro, I; Tellier, M; Nojima, T; Costa, AM; Freitas, J; Murphy, S; Oliveira, MJ; Proudfoot, NJ; Moreira, AMacrophages are essential cells of the immune system that alter their inflammatory profile depending on their microenvironment. Alternative polyadenylation in the 3'UTR (3'UTR-APA) and intronic polyadenylation (IPA) are mechanisms that modulate gene expression, in particular in cancer and activated immune cells. Yet, how polarization and colorectal cancer (CRC) cells microenvironment affect 3'UTR-APA and IPA in...
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker trigger...
Peixoto, A; Ferreira, D; Azevedo, R; Freitas, R; Fernandes, E; Relvas-Santos, M; Gaiteiro, C; Soares, J; Cotton, S; Teixeira, B; Paulo, P; Lima, LBackground: Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia and nutrient deprivation, oversialylation and O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential. Meth...
Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercis...
Rocha-Rodrigues, S; Matos, M; Afonso, J; Mendes-Ferreira, M; Abade, E; Teixeira, E; Silva, B; Murawska-Cialowicz, E; Oliveira, MJ; Ribeiro, RIncreased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these eff...
Hypoxia and macrophages act in concert towards a beneficial outcome in colon ca...
Martins, F; Oliveira, R; Cavadas, B; Pinto, F; Cardoso, AP; Castro, F; Sousa, B; Pinto, ML; Silva, AJ; Adão, D; Loureiro, JP; Pedro, N; Reis, RMIn colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...
Urinary biomarkers in bladder cancer: Where do we stand and potential role of e...
Oliveira, MC; Caires, HR; Oliveira, MJ; Fraga, A; Vasconcelos, MH; Ribeiro, RExtracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling. In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathol...
Nucleolin-sle a glycoforms as E-selectin ligands and potentially targetable bio...
Fernandes, E; Freitas, R; Ferreira, D; Soares, J; Azevedo, R; Gaiteiro, C; Peixoto, A; Oliveira, S; Cotton, S; Relvas-Santos, M; Afonso, LP; Palmeira, CBackground: Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis and efficient therapeutic targeting. Sialyl-Lewis A (SLeA), a terminal glycoepitope of glycoproteins and glycolipids, offers tremendous potential towards this objective. It is rarely expressed in healthy tissues and blood cells, whi...
Clinicopathological features as prognostic predictors of poor outcome in papill...
Póvoa, AA; Teixeira, E; Bella-Cueto, MR; Melo, M; Oliveira, MJ; Sobrinho-Simões, M; Maciel, J; Soares, PPapillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-...
Germline genetic variants of the renin-angiotensin system, hypoxia and angiogen...
Catarata, MJ; Medeiros, R; Oliveira, MJ; Pêgo, A; Frade, JG; Martins, MF; Cordeiro, CR; Herth, FJF; Thomas, M; Kriegsmann, M; Meister, M; Schneider, MAIntroduction: The renin–angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis. Methods: Geno...
Renin-angiotensin system in lung tumor and microenvironment interactions
Catarata, MJ; Ribeiro, R; Oliveira, MJ; Cordeiro, CR; Medeiros, RThe mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical...