83 documents found, page 1 of 9
Case Report: Mutation in NPPA Gene As a Cause of Fibrotic Atrial Myopathy
Silva Cunha, P; Antunes, D; Laranjo, S; Coutinho, A; Abecasis, J; Oliveira, MMEarly-onset atrial fibrillation (AF) can be the manifestation of a genetic atrial myopathy. However, specific genetic identification of a mutation causing atrial fibrosis is rare. We report a case of a young patient with an asymptomatic AF, diagnosed during a routine examination. The cardiac MRI revealed extensive atrial fibrosis and the electrophysiology study showed extensive areas of low voltage. The genetic...
Clinical Outcome of a Single Procedure Cryoballoon Ablation for the Treatment o...
Silva Cunha, P; Fonseca, P; Laranjo, S; Montenegro Sá, F; Valente, B; Portugal, G; Gonçalves, H; Nogueira da Silva, M; Brandão, L; Oliveira, MMBackground: Cryoballoon ablation (CBA) for pulmonary vein isolation (PVI) has been growing as an alternative technique, not only in patients with paroxysmal atrial fibrillation (PAF) but also in persistent atrial fibrillation (AF). Cryoballoon ablation has demonstrated encouraging acute and mid-term results. However, data on long-term follow-up of CB-based PVI are scarce. Objective: We sought to examine efficac...
Non-Vitamin K Oral Anticoagulants Assessment in High Risk of Bleeding Patients ...
Silva Cunha, P; Viveiros Monteiro, A; Coutinho Cruz, M; Malveiro, P; Reis, JP; Portugal, G; Dias, A; Cruz Ferreira, R; Oliveira, MMAtrial fibrillation (AF) is commonly associated with advanced age and the presence of multiple, concomitant acute and chronic health conditions, placing this population at high risk for serious therapeutic side effects. Nonvitamin K antagonist oral anticoagulants (NOACs) are increasingly used for stroke prevention in patients with atrial fibrillation. The purpose of this study was to investigate the effectivene...
A Systemic Review of Endocardial Left Ventricular Pacing
Santos, H; Santos, M; Almeida, I; Paula, S; Figueiredo, M; Portugal, G; Valente, B; Silva Cunha, P; Almeida, L; Oliveira, MMBackground: Endocardial left ventricular pacing is an alternative technique used in cardiac resynchronization therapy (CRT), when placement of a left ventricular lead is not possible via the coronary sinus or in non-responders to conventional CRT. Objectives: To review the evidence regarding the efficacy and safety of endocardial left ventricular pacing. Methods: Systematic research on Medline (PubMed), Clinica...
Long-Term Outcomes of Non-Contact Multi-Electrode Balloon Catheter Mapping-Guid...
Almeida, I; Lousinha, A; Silva Cunha, P; Valente, B; Paulo, M; Delgado, AS; Cruz Ferreira, R; Oliveira, MMIntroduction: The outflow tract (OT) regions of the ventricles are a common location of origin for idiopathic ventricular arrhythmias (VA). Non-contact mapping (NCM) with a multi-electrode balloon catheter Ensite-Array enables three-dimensional reconstruction of the geometry of the cardiac chambers and accurate mapping of the propagation map, based on a single beat analysis, facilitating the ablation and contri...
Castanea sativa mill. flowers as potential chemopreventive agent against rat pr...
Nascimento-Gonçalves, Elisabete; Silva, M; Seixas, Fernanda; Fardilha, Margarida; Ferreira, Rita; Neuparth, Maria João; Faustino-Rocha, Ana IsabelIntroduction: Prostate cancer is one of the most common cancer among men, having a huge impact in their health [1]. This work aimed to evaluate the influence of a decoction extract obtained from C. sativa flowers (CF) on chemically and hormonally induced rat prostate cancer animal model. Material & Methods: All the animal experiments were approved by the Institutional Animals Ethics Committee and by Portuguese ...
The influence of Castanea sativa Mill. flower extract on hormonally and chemica...
Nascimento-Gonçalves, E; Seixas, F; Silva, M; Fardilha, M; Ferreira, R; Neuparth, MJ; Faustino-Rocha, AI; Colaço, B; Venâncio, C; Barros, LProstate cancer (PCa) is one of the most common cancers in men, with a huge impact on their health. The use of Castanea sativa Mill. flowers (CFs) in beverages has been reported, through ancestral claims, as having health benefits. In vitro research has evidenced the properties of CFs, such as antitumor and anti- oxidant activities. This study aimed to evaluate the effects of CF extract in an animal model of PC...
The Atrium in Atrial Fibrillation - A Clinical Review on How to Manage Atrial F...
Silva Cunha, P; Laranjo, S; Heijman, J; Oliveira, MMAtrial fibrillation (AF) is the most common sustained arrhythmia in the population and is associated with a significant clinical and economic burden. Rigorous assessment of the presence and degree of an atrial arrhythmic substrate is essential for determining treatment options, predicting long-term success after catheter ablation, and as a substrate critical in the pathophysiology of atrial thrombogenesis. Cath...
Castanea sativa mill. flowers as potential chemopreventive agent against rat pr...
Nascimento-Gonçalves, Elisabete; Silva, M; Seixas, Fernanda; Fardilha, Margarida; Ferreira, Rita; Neuparth, Maria João; Faustino-Rocha, Ana Isabelntroduction: Prostate cancer is one of the most common cancer among men, having a huge impact in their health [1]. This work aimed to evaluate the influence of a decoction extract obtained from C. sativa flowers (CF) on chemically and hormonally induced rat prostate cancer animal model. Material & Methods: All the animal experiments were approved by the Institutional Animals Ethics Committee and by Portuguese n...
Impact of Substrate-Based Ablation for Ventricular Tachycardia in Patients with...
Oliveira, MM; Cunha, PS; Valente, B; Portugal, G; Lousinha, A; Pereira, M; Braz, M; Delgado, A; Cruz Ferreira, RIntroduction: Recurrent ventricular tachycardia (VT) episodes have a negative impact on the clinical outcome of implantable cardioverter-defibrillator (ICD) patients. Modification of the arrhythmogenic substrate has been used as a promising approach for treating recurrent VTs. However, there are limited data on long-term follow-up. Aim: To analyze long-term results of VT substrate-based ablation using high-dens...