3 documents found, page 1 of 1
Antileishmania, antimalarial and antitrypanosome potential of Casearia species:...
Oliveira, Maiara de Souza; Silva, Marjorie Caroline Picanço da; Cardoso, Pamela Brandão; Silva, Thiago Freitas; Brigido, Heliton Patrick CordovilOne of the greatest challenges in the treatment of parasitic diseases is the resistance developed by the parasites against the available drugs. Therefore, the search for therapeutic alternatives is urgent. This study carried out an integrative review of the literature that evaluated the antileishmanial, antimalarial and antitrypanosome potential of plants of the genus Casearia. The search for scientific article...
Ru(II)-thymine complex causes cell growth inhibition and induction of caspase-m...
Oliveira, Maiara de Souza; Santana, Adila Angélica Dantas de; Correa, Rodrigo de Souza; Soares, Milena Botelho Pereira; Batista, Alzir AzevedoRuthenium-based compounds represent a class of potential antineoplastic drugs. Recently, we designed, synthesized, and identified the Ru(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh = triphenylphosphine, Thy = thymine and bipy = 2,2′-bipyridine) as a potent cytotoxic agent with the ability to bind to DNA and human and bovine serum albumins. In this study, the underlying cytotoxic mechanism of the [R...
A novel platinum complex containing a piplartine derivative exhibits enhanced c...
Oliveira, Maiara de Souza; Barbosa, Marília Imaculada Frazão; Souza, Thiago Belarmino de; Moreira, Diogo Rodrigo de Magalhães; Martins, Felipe TerraPiplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigat...