13 documents found, page 1 of 2
Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by th...
Ciesielska, Elena J.; Kim, Shalom; Bisimwa, Hyacintha-ghislaine M.; Grier, Cody; Rahman, Md. Mostafijur; Young, Carolyn K.J.; Young, Matthew J.Made available in DSpace on 2022-04-29T08:35:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; The COVID-19 pandemic prompted the FDA to authorize a new nucleoside analogue, remdesivir, for emergency use in affected individuals. We examined the effects of its active metabolite, remdesivir triphosphate (RTP), on the activity of the replicative mitochondrial DNA polymerase, Pol γ. We found that whi...
An affordable and efficienthomemade platform for drosophila behavioral studies,...
Garcia, Geovana S. [UNESP]; Othonicar, Murilo F. [UNESP]; Oliveira, Marcos T. [UNESP]; Couto-Lima, Carlos A.Made available in DSpace on 2022-04-29T08:36:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; The usefulness of Drosophila as a model organism for the study of human diseases, behaviors and basic biology is unquestionable. Although practical, Drosophila research lacks popularity in developing countries, possibly due to the misinformed idea that establishing a lab and performing relevant experime...
Stimulation of Variant Forms of the Mitochondrial DNA Helicase Twinkle by the M...
Rodrigues, Ana P. C. [UNESP]; Oliveira, Marcos T. [UNESP]Made available in DSpace on 2022-04-29T08:29:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Defects in mitochondrial DNA (mtDNA) maintenance may lead to disturbances in mitochondrial homeostasis and energy production in eukaryotic cells, causing diseases. During ...
The Essential, Ubiquitous Single-Stranded DNA-Binding Proteins
Oliveira, Marcos T. [UNESP]; Ciesielski, Grzegorz L.Made available in DSpace on 2022-04-29T08:29:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Auburn University at Montgomery; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Maintenance of genomes is fundamental for all living organisms. The diverse processes related to genome maintenance entail the management ...
Alternative oxidase confers nutritional limitation on Drosophila development
Saari, Sina; Kemppainen, Esko; Tuomela, Tea; Oliveira, Marcos T. [UNESP]; Dufour, Eric; Jacobs, Howard T.Made available in DSpace on 2021-06-25T12:38:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01; FP7 Ideas: European Research Council; Tampere University Hospital Medical Research Fund; Suomen Akatemia; Sigrid Juselius Foundation; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The mitochondrial alternative oxidase...
Regulated hypothermia in response to endotoxin in birds
Amaral-Silva, Lara do [UNESP]; Gargaglioni, Luciane H. [UNESP]; Steiner, Alexandre A.; Oliveira, Marcos T. [UNESP]; Bicego, Kenia Cardoso [UNESP]Made available in DSpace on 2021-06-25T15:03:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-03; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Key points The costs associated with immune and thermal responses may exceed the benefits to the host during severe inflammation. In this case, regulated hypothermia instead of fever can occur in rodents as a beneficial strategy to conserve ...
Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanog...
Salminen, Tiina S.; Cannino, Giuseppe; Oliveira, Marcos T. [UNESP]; Lillsunde, Paivi; Jacobs, Howard T.; Kaguni, Laurie S.Made available in DSpace on 2019-10-04T12:39:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01; Academy of Finland; National Institutes of Health; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); EU (Marie Curie International Incoming Fellowship); Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). ...
Structural rearrangements in the mitochondrial genome of Drosophila melanogaste...
Ciesielski, Grzegorz L.; Nadalutti, Cristina A.; Oliveira, Marcos T. [UNESP]; Jacobs, Howard T.; Griffith, Jack D.; Kaguni, Laurie S.Made available in DSpace on 2018-11-26T17:48:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-04-06; National Institutes of Health; Academy of Finland; University of Tampere; Michigan State University; Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a ...
Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA rep...
Rodrigues, Ana Paula C. [UNESP]; Camargo, Andre F. [UNESP]; Andjelkovic, Ana; Jacobs, Howard T.; Oliveira, Marcos T. [UNESP]Made available in DSpace on 2018-11-26T17:54:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-07-18; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Finnish Cultural Foundation; European Research Council; Academy of Finland; Tampere University Medical Research Fund; Sigrid Juselius Foundation; The xenotopic expression o...
Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in ...
Salminen, Tiina S.; Oliveira, Marcos T. [UNESP]; Cannino, Giuseppe; Lillsunde, Paivi; Jacobs, Howard T.; Kaguni, Laurie S.Made available in DSpace on 2018-11-26T17:33:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-05-01; Academy of Finland; National Institutes of Health; Marie Curie International Incoming Fellowship Program; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits...