INTRODUÇÃO: Os endoleaks tipo II são a complicação e causa de reintervenção mais frequente do EVAR sendo, contudo, tema de debate entre a comunidade científica. Este trabalho tem como objetivo rever as diferentes abordagens aos endoleaks tipo II após reparação endovascular de aneurismas da aorta infrarrenal. MATERIAIS E MÉTODOS: Para a realização deste trabalho os autores selecionaram e analisaram ...
Background and Aims: Ambulatory surgery (AS) has increased rapidly in most countries since the 1990’s. There is an increasing effort by national healthcare systems to disseminate clinical information about this type of surgical environment to their populations. We conducted a public survey to understand what citizens think about AS and its organization in countries across the world. Methods: This prospective ob...
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease often associated with severe complications that may result in patient morbidity or death. One T2DM etiological agent is chronic hyperglycemia, a condition that induces damaging biological processes, including impactful extracellular matrix (ECM) modifications, such as matrix components accumulation. The latter alters ECM stiffness, triggering fibros...
Radiotherapy (RT) is an essential treatment modality for several types of cancer. Despite its therapeutic potential, RT is frequently insufficient to overcome the immunosuppressive nature of the tumor microenvironment, failing to control tumor metastases. Innovative immunomodulatory strategies, like immunostimulatory biomaterials could be used to boost the immunogenic effects of RT. Herein, we addressed the syn...
Extracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling. In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathol...
Macrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
Gregório Lopes (1490-1550) foi um dos pintores mais proeminentes do Renascimento e Maneirismo Português. A pintura "Mater Misericordiae", feita para a Santa Casa da Misericórdia de Sesimbra, cerca de 1535-1538, e actualmente no Núcleo Museológico da Capela do Espírito Santo de Sesimbra, é uma das obras mais importantes do artista, e a sua única pintura sobre esta temática, sendo, como tal, uma das pinturas mais...
Macrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
Grego´rio Lopes (c. 1490–1550) was one of the most prominent painters of the renaissance and Mannerism in Portugal. The painting “Mater Misericordiae” made for the Sesimbra Holy House of Mercy, circa 1535–1538, is one of the most significant works of the artist, and his only painting on this theme, being also one of the most significant Portuguese paintings of sixteenth century. The recent restoration provided ...
The visible polychromy of a wooden sculpture representing St. John the Evangelist, from Museu Nacional de Arte Antiga, Lisbon (Portugal) presents several techniques that complement each other on the creation of a sumptuous estofado. This case-study allowed the survey on gilding, silvering and polychromy practices, and observations on their execution are briefly reported and documented with results from a multi-...