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A molecular biophysical approach to diclofenac topical gastrointestinal damage

Fernandes, Eduarda; Soares, Telma; Gonçalves, Hugo; Bernstorff, Sigrid; Oliveira, Maria Real; Lopes, Carla Martins; Lúcio, Marlene

Diclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications. The present study aims to better understand the topical toxicity induced by DCF using membrane models that mimic the physiological, biophysical, and chemical environments of GI mucosa segments. For this purpose, phospholipid...

Date: 2018   |   Origin: Repositório Institucional - Universidade Fernando Pessoa
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