3 documents found, page 1 of 1
Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia
Oliveira, Mariana L.; Veloso, Alexandra; Garcia, Elaine G.; Iyer, Sowmya; Pereira, Clara; Barreto, Vasco M.; Langenau, David M.; Barata, João T.T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric cancer. Amongst the wide array of driver mutations, 10% of T-ALL patients display gain-of-function mutations in the IL-7 receptor α chain (IL-7Rα, encoded by IL7R), which occur in different molecular subtypes of this disease. However, it is still unclear whether IL-7R mutational activation is sufficient to transform T-cell precursors. Also, ...
Interleukin-7 receptor α mutational activation can initiate precursor B-cell ac...
Almeida, Afonso; Neto, João Luís; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta; Raposo, Beatriz; Oliveira, Mariana L.Interleukin-7 receptor α (encoded by IL7R) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, establishes a pre-leukemic stage in which B-cell precursors display self-renewal a...
IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: an update
Oliveira, Mariana L.; Akkapeddi, Padma; Ribeiro, Daniel; Melão, Alice; Barata, João T.Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. In their absence, severe combined immunodeficiency occurs. By contrast, excessive IL-7/IL-7R-mediated signaling can drive lymphoid leukemia development, disease acceleration and resistance to chemotherapy. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ulti...