7 documents found, page 1 of 1
Differential expression of proteins in genetically distinct Trypanosoma cruzi s...
Oliveira, Maykon Tavares de; Rúbio, Karina Taciana Santos; Neves, Leandro Xavier; Toledo, Max Jean de Ornelas; Borges, William de Castro; Lana, Marta deBackground Trypanosoma cruzi, a hemoflagellate protozoan parasite and the etiological agent of Chagas disease (CD), exhibits great genetic and biological diversity. Infected individuals may present clinical manifestations with different levels of severity. Several hypotheses have been proposed to attempt to correlate the diversity of clinical signs and symptoms to the genetic variability of T. cruzi. This work ...
Propriedades biológicas fundamentais de diferentes grupos genéticos do Trypanos...
Oliveira, Maykon Tavares dePrograma de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; A Doença de Chagas (DCh) tem como agente etiológico o protozoário hemoflagelado Trypanosoma cruzi que apresenta grande diversidade genética, que por sua vez apresenta-se relacionada à diversidade biológica da espécie. Diversas estudo foram ...
Host-parasite interactions in chagas disease : genetically unidentical isolates...
Paiva, Nívia Carolina Nogueira de; Vieira, Paula Melo de Abreu; Oliveri, Larissa Maris Rezende; Fonseca, Kátia da SilvaThe present study aims at establishing whether the diversity in pathogenesis within a genetically diverse host population infected with a single polyclonal strain of Trypanosoma cruzi is due to selection of specific subpopulations within the strain. For this purpose we infected Swiss mice, a genetically diverse population, with the polyclonal strain of Trypanosoma cruzi Berenice-78 and characterized via LSSP-PC...
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated fr...
Silva, Jaquelline Carla Valamiel de Oliveira e; Assis, Girley Francisco Machado de; Oliveira, Maykon Tavares de; Paiva, Nívia Carolina Nogueira deTrypanosoma cruzi strains from distinct geographic areas show differences in drug resistance and association between parasites genetic and treatment response has been observed. Considering that benznidazole (BZ) can reduce the parasite burden and tissues damage, even in not cured animals and individuals, the goal is to assess the drug response to BZ of T. cruzi II strains isolated from children of the Jequitinh...
Trypanosoma cruzi Discret Typing Units (TcII and TcVI) in samples of patients f...
Oliveira, Maykon Tavares de; Assis, Girley Francisco Machado de; Silva, Jaquelline Carla Valamiel de Oliveira e; Machado, Evandro Marques de MenezesBackground: Trypanosoma cruzi is classified into six discrete taxonomic units (DTUs). For this classification, different biological markers and classification criteria have been used. The objective was to identify the genetic profile of T. cruzi samples isolated from patients of two municipalities of Jequitinhonha Valley, MG, Brazil. Methods: Molecular characterization was performed using two different criteria...
Molecular and biological characterization of Trypanosoma cruzi strains isolated...
Silva, Jaquelline Carla Valamiel de Oliveira e; Assis, Girley Francisco Machado de; Oliveira, Maykon Tavares de; Valadares, Helder Magno SilvaThe biological diversity of Trypanosoma cruzi strains plays an important role in the clinical and epidemiological features of Chagas disease. Methods: Eight T. cruzi strains isolated from children living in a Chagas disease vector-controlled area of Jequitinhonha Valley, State of Minas Gerais, Brazil, were genetically and biologically characterized. Results: The characterizations demonstrated that all of the st...
Genotipagem de amostras de Trypanosoma cruzi isoladas de pacientes chagásicos d...
Oliveira, Maykon Tavares deA espécie do Trypanosoma cruzi possui uma estrutura genética que permite a subdivisão intraespecífica em seis grupos genéticos distintos, denominados TcI, TcII, TcIII, TcIV, TcV e TcVI (Zingales et al., 2009) que tem apresentado diferenças frente a distribuição geográfica, propriedades biológicas e susceptibilidade a droga. É conhecido o predomínio das DTU’s TcII e TcVI em diversas regiões Brasileiras, associad...