8 documents found, page 1 of 1
Oxidative injury in V79 Chinese hamster cells: protective
Fernandes, Ana S.; Serejo, João; Gaspar, Jorge; Cabral, Fátima; Bettencourt, Ana F.; Rueff, José; Castro, Matilde; Costa, Judite; Oliveira, Nuno G.Oxidative cell injury could be induced by different reactive oxygen species (ROS) operating in multiple pathways. The present work is focused on three different models of oxidative stress: the xanthine/xanthine oxidase system (XXO), an extracellular superoxide anion generator; tert-butylhydroperoxide (TBHP), an analogue of lipid hydroperoxides; and doxorubicin (Dox), an anticancer drug. Superoxide and peroxyl r...
Cytotoxicity and chromosomal aberrations induced by acrylamide in V79 cells
Oliveira, Nuno G.; Pingarilho, Marta; Martins, Celia; Fernandes, Ana Sofia; Vaz, Sofie; Martins, Vanda; Rueff, Jose; Gaspar, Jorge FranciscoAcrylamide (AA) is a suspected human carcinogen found to be generated during the heating of carbohydrate-rich foodstuffs. AA exhibits 'Michael-type' reactivity towards reduced glutathione (GSH), resulting in vivo in the urinary excretion of mercapturic acid conjugates. GSH is a key factor for mammalian cell homeostasis, with diverse functions that include, among others, the Conjugation of electrophilic compound...
Evaluation of the protective effect of MnTMPyP on the cytotoxicity induced by d...
Fernandes, Ana Sofia; Gaspar, Jorge; Cabral, M. Fatima; Bettencourt, Ana F.; Caneiras, Catla; Rueff, Jose; Castro, Matilde; Costa, Judite
Macrocyclic copper(II) complexes
Fernandes, Ana S.; Gaspar, Jorge; Cabral, M. Fatima; Caneiras, Catia; Guedes, Rita; Rueff, Jose; Castro, Matilde; Costa, Judite; Oliveira, Nuno G.Synthetic superoxide dismutase mimetics have emerged as a potential novel class of drugs for the treatment of oxidative stress related diseases. Among these agents, metal complexes with macrocyclic ligands constitute an important group. In this work we synthesized five macrocyclic copper(II) complexes and evaluated their ability to scavenge the superoxide anions generated by the xanthine-xanthine oxidase system...
Pyridine-containing macrocyclic copper(II) complexes
Fernandes, Ana S.; Oliveira, Nuno G.; Gaspar, Jorge; Cabral, M. Fatima; Caneiras, Catia; Rueff, Jose; Castro, Matilde; Costa, Judite
Evaluation of cytotoxicity and oxidative stress induced by acrylic bone cement ...
Bettencourt, Ana F.; Fernandes, Ana S.; Oliveira, Nuno G.; Monteiro, Jacinto; Calado, Antonio; Castro, Matilde
Novel copper(II) macrocyclic complexes with superoxide scavenging activity
Fernandes, Ana Sofia; Cabral, M. Fatima; Rueff, Jose; Caneiras, Catia; Gaspar, Jorge; Castro, Matilde; Costa, Judite; Oliveira, Nuno G.
Induction of an adaptive response to quercetin, mitomycin C and hydrogen peroxi...
Oliveira, Nuno G.; Rodrigues, A. S.; Chaveca, T.; Rueff, J.The adaptive response is a phenomenon by which cells exposed to low, non-cytotoxic doses of a genotoxicant become significantly resistant to a subsequent higher dose of the same or another genotoxic agent. Induction of the adaptive response has been mainly studied using ionizing radiation and alkylating agents as genotoxic agents. However, other mutagenic agents may warrant further study, since the adaptive res...