24 documents found, page 1 of 3

Intra-urban variation in tuberculosis and community socioeconomic deprivation i...

Background: Multidrug resistant tuberculosis (MDR-TB) is a recognized threat to global efforts to TB control and remains a priority of the National Tuberculosis Programs. Additionally, social determinants and socioeconomic deprivation have since long been associated with worse health and perceived as important risk factors for TB. This study aimed to analyze the spatial distribution of non-MDR-TB and MDR-TB acr...

Evaluation of drug-resistant tuberculosis treatment outcome in Portugal, 2000-2016

Treatment of drug-resistant tuberculosis (TB), which is usually less successful than that of drug-susceptible TB, represents a challenge for TB control and elimination. We aimed to evaluate treatment outcomes and to identify the factors associated with death among patients with MDR and XDR-TB in Portugal. We assessed MDR-TB cases reported for the period 2000-2016, using the national TB Surveillance System. Trea...

Using Bayesian spatial models to map and to identify geographical hotspots of m...

Multidrug-resistant tuberculosis (MDR-TB) is a major threat to the eradication of tuberculosis. TB control strategies need to be adapted to the necessities of different countries and adjusted in high-risk areas. In this study, we analysed the spatial distribution of the MDR- and non-MDR-TB cases across municipalities in Continental Portugal between 2000 and 2016. We used Bayesian spatial models to estimate age-...

Factors associated with loss to follow-up in Tuberculosis treatment in the Huam...

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Mycobacterial blood cultures in the diagnosis of tuberculosis in human immunode...

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A nationwide study of multidrug-resistant tuberculosis in Portugal 2014-2017 us...

ackground Increasing multidrug-resistant tuberculosis (MDR-TB) incidence is a major threat against TB eradication worldwide. We aim to conduct a detailed MDR-TB study in Portugal, an European country with endemic TB, combining genetic analysis and epidemiological data, in order to assess the efficiency of public health containment of MRD-TB in the country. Methods We used published MIRU-VNTR data, that we reana...

Association of leukotriene A4 hydrolase with tuberculosis susceptibility using ...

Leukotriene A4 hydrolase (LTA4H) is a key enzyme in the eicosanoid pathway. lta4h locus polymorphisms have previously been linked to tuberculosis (TB) susceptibility and disease outcome in a Vietnamese dataset, but further studies suggested that those results were poorly reproducible. We, therefore, compared the full set of variants (113 SNPs) within the gene in a Portuguese dataset of 112 TB patients and 120 c...

Immigrants' access to health care: Problems identified in a high-risk tuberculo...

Introduction Immigrants may utilize health care services differently than other residents and may also have a greater risk for tuberculosis (TB). Objective Identify barriers to healthcare access by immigrants, factors associated with these barriers, and discuss strategies that may reduce these barriers. Material and methods Anonymous questionnaires were given to immigrants at National Immigrant Support Centres ...

Tuberculosis incidence rate among the homeless population: The impact of socio-...

Effect of Isoniazid Resistance on the Tuberculosis Treatment Outcome