12 documents found, page 1 of 2
Addressing new therapeutic strategies using models
Faustino-Rocha, Ana; Oliveira, Paula AA disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, establishing the pathophysiology of a disease, and testing potential therapeutic approaches.Models have been long used to study several diseases, including cardiovascular, oncol...
The lifestyle of the leopard gecko and the importance of ultraviolet radiation,...
Franco, F; Oliveira, Paula A; Patrício, Rui; Faustino-Rocha, Ana IThe gecko leopard (Eublepharis macularius) was first described in 1854 by British herpetol- ogist Edward Blyth. It is one of the most pop- ular pet lizard species, due to its docile tem- perament, ease of maintenance and reproduc- tion in captivity, its high longevity and small size, and its beauty and diversity of colours and patterns. Ultraviolet (UV) radiation is an important behavioural regulator. Vitamin D...
Letter to the Editor. Re: Comparing variability in measurement of subcutaneous ...
Faustino-Rocha, Ana I; Oliveira, Paula AWe read with great interest the article entitled “Comparing variability in measurement of subcutaneous tumors in mice using 3D thermal imaging and calipers.”1 This research aimed to determine whether the previously observed lower variability on interoperator repeats in the measurement of subcutaneous tumors in mice could be reproduced in a larger dataset.1 We congratulate the authors for this original article a...
The impact of resveratrol-enriched bread on cardiac remodeling in a preclinical...
Silva, AFR; Silva-Reis, R; Ferreira, R; Oliveira, Paula A; Faustino-Rocha, Ana I; Pinto, ML; Coimbra, MA; Silva, AMS; Cardoso, SAbstract The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate th...
Canine and feline papillomaviruses: an update
Medeiros-Fonseca, B; Faustino-Rocha, Ana I; Medeiros, R; Oliveira, Paula A; Gil da Costa, RMPapillomaviruses are small viruses able to cause disease not only in mammalians, but also in birds and reptiles. In recent years, a rising number of papillomaviruses have been identified in dogs and cats, totaling 24 canine papillomavirus (CPV) and six feline papillomavirus (FcaPV). The canine and feline papillomaviruses (CPVs and FcaPVs, respectively) are responsible for multiple lesions in these domestic spec...
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...
Evaluating the impact of a western diet on biochemical parameters in an animal ...
Silva, A; Azevedo, T; Anjos, L; Faustino-Rocha, Ana I; Oliveira, Paula A; Duarte, JABreast cancer continues to affect millions of individuals worldwide. In this way, it is of paramount importance to understand the effects of dietary choices in this disease development. This work aimed to evaluate the influence of Western diet (WD) on biochemical parameters in an animal model of breast cancer. Twenty-eight female Wistar rats were divided into four groups (n=7): WD; WD+N-methyl- N-nitrosourea (M...
Addressing new therapeutic strategies using models
Faustino-Rocha, Ana I; Oliveira, Paula AA disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, to establish the pathophysiology of a disease, and to test potential therapeutic approaches. Models have been long used to study several diseases, including cardiovascular, onco...
Lifelong exercise training promotes the remodelling of the immune system and pr...
Nascimento-Gonçalves, Elisabete; Seixas, Fernanda; Palmeira, Carlos; Martins, Gabriela; Fonseca, Carolina; Duarte, José Alberto; Faustino-Rocha, Ana IThis work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administratio...
Modelos de cancro da mama: do in vitro para o in vivo
Silva, Jessica; Faustino-Rocha, Ana I; Oliveira, Paula A; Duarte, José AlbertoA incidência e mortalidade de cancro da mama têm vindo a aumentar ao longo dos anos. Esta doença foi descrita pela primeira vez no ano 3000 a.C. por Edwin Smith Papyrus como uma doença grave sem tratamento conhecido. Atualmente, continua a ser necessário o delineamento de estratégias de prevenção, deteção e tratamento do cancro da mama. Para tal, é extremamente importante a utilização de modelos alternativos ao...