128 documents found, page 1 of 13
Chemical Characterization and Differential Lipid-Modulating Effects of Selected...
Amorim, Ricardo; Marques, Mário Pedro; Melim, Catarina; Varela, Carla; Sardão, Vilma A.; Teixeira, José; Dias, Maria Inês; Barros, LillianCôa Valley, located in the northeast of Portugal, harbors more than 500 medicinal plant species. Among them, four species stand out due to their traditional uses: Equisetum ramosissimum Desf. (hemorrhages, urethritis, hepatitis), Rumex scutatus L. subsp. induratus (Boiss. and Reut.) Malag. (inflammation, constipation), Geranium purpureum Vill., and Geranium lucidum L. (pain relief, gastric issues). Given their ...
Best practices for data management and sharing in experimental biomedical research
Cunha-Oliveira, Teresa; Ioannidis, John P. A.; Oliveira, Paulo J.Effective data management is crucial for scientific integrity and reproducibility, a cornerstone of scientific progress. Well-organized and well-documented data enable validation and building on results. Data management encompasses activities including organization, documentation, storage, sharing, and preservation. Robust data management establishes credibility, fostering trust within the scientific community ...
Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Shift in the Left...
Grilo, Luís F.; Zimmerman, Kip D.; Puppala, Sobha; Chan, Jeannie; Huber, Hillary F.; Li, Ge; Jadhav, Avinash Y. L.; Wang, Benlian; Li, CunAge is a prominent risk factor for cardiometabolic disease, often leading to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction exclusively resulting from physiological aging remain elusive. Previous research demonstrated age-related functional alterations in baboons, analogous to humans. The goal of this study is to identify early cardia...
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plect...
Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Massenzio, Francesca; Spigarelli, RenatoGlioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-be...
Age-associated metabolic and epigenetic barriers during direct reprogramming of...
Santos, Francisco; Correia, Magda; Dias, Rafaela; Bola, Bárbara; Noberini, Roberta; Ferreira, Rita S.; Trigo, Diogo; Domingues, Pedro; Teixeira, JoséHeart disease is the leading cause of mortality in developed countries, and novel regenerative procedures are warranted. Direct cardiac conversion (DCC) of adult fibroblasts can create induced cardiomyocytes (iCMs) for gene and cell-based heart therapy, and in addition to holding great promise, still lacks effectiveness as metabolic and age-associated barriers remain elusive. Here, by employing MGT (Mef2c, Gata...
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabol...
Afonso, Marta B.; Islam, Tawhidul; Magusto, Julie; Amorim, Ricardo; Lenoir, Véronique; Simões, Rui F.; Teixeira, José; Silva, Liana C.Background and Aims: Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD) architecture in NAFLD. Approach and Results: Functional studies evaluating mitochondria and LD biology were performed in wild‐type (WT) and Ripk3−/− mice fed a cho...
Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolys...
Bessa, Cláudia; Loureiro, Joana B.; Barros, Matilde; Isca, Vera M. S.; Sardão, Vilma A.; Oliveira, Paulo J.; Bernardino, Raquel L.Metabolic reprogramming is a central hub in tumor development and progression. Therefore, several efforts have been developed to find improved therapeutic approaches targeting cancer cell metabolism. Recently, we identified the 7a-acetoxy-6b-benzoyloxy-12-O-benzoylroyleanone (Roy- Bz) as a PKC -selective activator with potent anti-proliferative activity in colon cancer by stimulating a PKC -dependent mitochondr...
Exposure to Obesogenic Environments during Perinatal Development Modulates Offs...
Sousa, Diana; Sá-Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, TamaehObesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: mat...
TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to...
Rego, Inês Ramos; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; Kong, YangAge-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumulation of reactive oxygen species (ROS) produced mainly by mitochondria. Tumor necrosis factor receptor-associated...
Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell D...
Castelão-Baptista, José P.; Valente, Sara A.; Canário, Sara; Oppolzer, David; Barros, Ana; Venâncio, Carlos; Martins, Tânia; Antunes, LuísObesity, a rising concern in the Eastern world, encompasses several co-morbidities, namely non-alcoholic fatty liver disease (NAFLD). Potential natural-based interventions to decrease the burden of obesity complications are being investigated. Many of the edible parts of plants are not sold for consumption and end up as massive waste, losing nutritional potential. In fact, a sizeable amount of waste is generate...