44 documents found, page 1 of 5

Rumo ao Mar: Avaliação Da Migração De Juvenis De Salmão-do-Atlântico (Salmo sal...

O salmão-do-atlântico (Salmo salar L., 1758) é uma espécie piscícola migradora icónica dos ecossistemas aquáticos, com um elevado valor económico e cultural, cuja área de distribuição se localiza desde o mar Báltico até ao norte da Península Ibérica. Em Portugal, as populações de salmão encontram-se no limite sul da sua distribuição e, portanto, em condições sub-ótimas associadas com o regime térmico e variaçõe...

A rare case of syphilitic uveitis in a 61-year-old non-HIV woman

Mecânica de Fluídos Computacional Aplicada ao Estudo do Impacto de Perfurações ...

Objetivos: Utilização de mecânica de fluídos computacional (MFC) na compreensão do impacto do tamanho e localização das perfurações septais (SP) na fisiologia nasal. Desenho de estudo: Estudo de simulação computacional. Material e Métodos: O Software de MFC (Flowgy®) foi utilizado na criação de modelos digitais de fossas nasais através da reconstrução de tomografias computadorizadas (TC). Foi realizada cirurgia...

Toward a Common Performance and Effectiveness Terminology for Digital Proximity...

Digital proximity tracing (DPT) for Sars-CoV-2 pandemic mitigation is a complex intervention with the primary goal to notify app users about possible risk exposures to infected persons. DPT not only relies on the technical functioning of the proximity tracing application and its backend server, but also on seamless integration of health system processes such as laboratory testing, communication of results (and ...

The cdh1 c.1901c>t variant: A founder variant in the portuguese population w...

Hereditary diffuse gastric cancer (HDGC) caused by CDH1 variants predisposes to early-onset diffuse gastric (DGC) and lobular breast cancer (LBC). In Northern Portugal, the unusually high number of HDGC cases in unrelated families carrying the c.1901C>T variant (formerly known as p.A634V) suggested this as a CDH1-founder variant. We aimed to demonstrate that c.1901C>T is a bona fide truncating variant inducing ...

The novel ECF56 SigG1-RsfG system modulates morphological differentiation and m...

Extracytoplasmic function (ECF) sigma factors are key transcriptional regulators that prokaryotes have evolved to respond to environmental challenges. Streptomyces tsukubaensis harbours 42 ECFs to reprogram stress-responsive gene expression. Among them, SigG1 features a minimal conserved ECF s2–s4 architecture and an additional C-terminal extension that encodes a SnoaL_2 domain, which is characteristic for ECF ...

Hypoxia and macrophages act in concert towards a beneficial outcome in colon ca...

In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...

The onset of tacrolimus biosynthesis in streptomyces tsukubaensis is dependent ...

The oxidative stress response is a key mechanism that microorganisms have to adapt to changeling environmental conditions. Adaptation is achieved by a fine-tuned molecular response that extends its influence to primary and secondary metabolism. In the past, the role of the intracellular redox status in the biosynthesis of tacrolimus in Streptomyces tsukubaensis has been briefly acknowledged. Here, we investigat...

Recommendations for genetic testing in cardiology: Review of major internationa...

In recent years, the importance of genetic causes of cardiovascular diseases has been increasingly recognized, as the result of significant advances in molecular diagnosis techniques. This growing knowledge has enabled the identification of new phenotypes and the subclassification of clinical syndromes, impacting the therapeutic approach and genetic counseling offered to affected families. This paper describes ...

Direct oral anticoagulants for the management of venous thromboembolism in pati...