5 documents found, page 1 of 1
Examination of raw samples and ethanol extracts of Gerês Propolis collected in ...
Caetano, Ana Rita; Oliveira, Rafaela Dias; Pereira, Rui Filipe Cerqueira; Cardoso, Tiago Vidal; Cardoso, Andreia; Almeida Aguiar, CristinaPropolis, a natural resin created by bees, has garnered significant attention from both the scientific community and industry due to an impressive range of bioactivities. Nonetheless, the intrinsic variability in its chemical composition and bioactive profiles has been hindering propolis' full potential use. We previously showed that ethanol extracts (EEs) of a Portuguese propolis sample (Gerês) collected over ...
Phenolic compounds contribution to portuguese propolis anti-melanoma activity
Caetano, Ana Rita; Oliveira, Rafaela Dias; Celeiro, Sónia Pires; Freitas, Ana Sofia; Cardoso, Susana M.; Gonçalves, M. Sameiro T.; Baltazar, FátimaMelanoma is the deadliest type of skin cancer, with about 61,000 deaths annually worldwide. Late diagnosis increases mortality rates due to melanoma’s capacity to metastasise rapidly and patients’ resistance to the available conventional therapies. Consequently, the interest in natural products as a strategy for drug discovery has been emerging. Propolis, a natural product produced by bees, has several biologic...
Assessing the in vitro antimicrobial and antitumor activity of portuguese propolis
Oliveira, Rafaela DiasO própolis é um produto natural resinoso produzido por abelhas melíferas. Diferentes grupos de compostos têm sido identificados no própolis e associados a diversas bioatividades. Algumas amostras de própolis Português exibem potencial antioxidante e antimicrobiano pelo que, neste trabalho, se avaliou esses atributos numa amostra de própolis obtida no Gerês em 2018. A atividade antitumoral do própolis Português ...
An insight on the biomedical potential of portuguese propolis from Gerês
Araújo, Carina; Oliveira, Rafaela Dias; Pinto-Ribeiro, Filipa; Almeida Aguiar, CristinaOsteoarthritis (OA), a progressive degenerative disease of weight-bearing joints, is the second leading cause of disability in the world. Despite all the advances and research over the last years, none of the proposed strategies has been effective in generating functional and long-lasting tissue. Due to the high prevalence of OA and the urgent need for an effective and successful treatment, interest in natural ...
Portuguese propolis antitumoral activity in melanoma involves ROS production an...
Oliveira, Rafaela Dias; Celeiro, Sónia Pires; Barbosa-Matos, Catarina; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, MartaMelanoma is the most aggressive and life-threatening skin cancer type. The melanoma genome is the most frequently mutated, with the <i>BRAF</i> mutation present in 40–60% of melanoma cases. <i>BRAF</i>-mutated melanomas are characterized by a higher aggressiveness and progression. Adjuvant targeted treatments, such as BRAF and MEK inhibitors, are added to surgical excision in <i>BRAF</i>-mutated metastatic mela...