36 documents found, page 1 of 4
Synthetic peptides elicit strong cellular immunity in Visceral Leishmaniasis na...
Brito, Rory Cristiane Fortes de; Cardoso, Jamille Mirelle de Oliveira; Reis, Levi Eduardo Soares; Mathias, Fernando Augusto SiqueiraReverse vaccinology or immunoinformatics is a computational methodology which integrates data from in silico epitope prediction, associated to other important information as, for example, the predicted subcellular location of the proteins used in the design of the context of vaccine development. This approach has the potential to search for new targets for vaccine development in the predicted proteome of pathog...
Experimental and clinical treatment of Chagas disease : a review.
Sales Júnior, Policarpo Ademar; Molina, Israel; Murta, Silvane Maria Fonseca; Sánchez Montalvá, Adrián; Salvador, Fernando; Oliveira, Rodrigo Corrêa deChagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a broad range of triatomines and mammalian species, including man. It afflicts 8 million people in Latin America, and its incidence is increasing in nonendemic countries owing to rising international immigration and nonvectorial transmission routes such as blood donation. Since the 1960s, the only drugs available for the clin...
Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features...
Resende, Lucilene Aparecida; Soares, Rodrigo Dian de Oliveira Aguiar; Ker, Henrique Gama; Roatt, Bruno Mendes; Mendonça, Ludmila Zanandreis deFundação de Amparo a Pesquisa do Estado de Minas Gerais. Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil/Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas/NUPEB Laboratório de Imunopatologia. Ouro Preto, MG, Brazil; Uni...
An assessment on epitope prediction methods for protozoa genomes.
Resende, Daniela de Melo; Rezende, Antonio Mauro; Oliveira, Nesley Jesus Daher de; Batista, Izabella Cristina Andrade; Oliveira, Rodrigo Corrêa deBackground: Epitope prediction using computational methods represents one of the most promising approaches to vaccine development. Reduction of time, cost, and the availability of completely sequenced genomes are key points and highly motivating regarding the use of reverse vaccinology. Parasites of genus Leishmania are widely spread and they are the etiologic agents of leishmaniasis. Currently, there is no eff...
LBSapSal-vaccinated dogs exhibit increased circulating T-lymphocyte subsets (CD...
Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno Mendes; Ker, Henrique Gama; Moreira, Nádia das Dores; Mathias, Fernando Augusto SiqueiraBackground: The development of a protective vaccine against canine visceral leishmaniasis (CVL) is an alternative approach for interrupting the domestic cycle of Leishmania infantum. Given the importance of sand fly salivary proteins as potent immunogens obligatorily co-deposited during transmission of Leishmania parasites, their inclusion in an anti-Leishmania vaccine has been investigated in the last few deca...
A vaccine therapy for canine visceral leishmaniasis promoted significant improv...
Roatt, Bruno Mendes; Soares, Rodrigo Dian de Oliveira Aguiar; Reis, Levi Eduardo Soares; Cardoso, Jamille Mirelle de OliveiraHerein, we evaluated the treatment strategy employing a therapeutic heterologous vaccine composed of antigens of Leishmania braziliensis associated with MPL adjuvant (LBMPL vaccine) for visceral leishmaniasis (VL) in symptomatic dogs naturally infected by Leishmania infantum. Sixteen dogs received immunotherapy with MPL adjuvant (n = 6) or with a vaccine composed of antigens of L. braziliensis associated with M...
Multicomponent LBSap vaccine displays immunological and parasitological profile...
Mendonça, Ludmila Zanandreis de; Resende, Lucilene Aparecida; Lanna, Mariana Ferreira; Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno MendesBackground: In past years, many researchers have sought canine visceral leishmaniasis (CVL) prevention through the characterization of Leishmania antigens as vaccine candidates. Despite these efforts, there is still no efficient vaccine for CVL control. Methods: In the present study, we performed a pre-clinical vaccine trial using BALB/c mice to compare the effects of the multicomponent LBSap vaccine with those...
Immunoinformatics features linked to leishmania vaccine development : data inte...
Brito, Rory Cristiane Fortes de; Guimarães, Frederico Gonçalves; Velloso, João Paulo Linhares; Oliveira, Rodrigo Corrêa de; Ruiz, Jeronimo ConceiçãoLeishmaniasis is a wide-spectrum disease caused by parasites from Leishmania genus. There is no human vaccine available and it is considered by many studies as apotential effective tool for disease control. To discover novel antigens, computational programs have been used in reverse vaccinology strategies. In this work, we developed a validation antigen approach that integrates prediction of B and T cell epitop...
Pharmacokinetic and tissue distribution of benznidazole after oral administrati...
Melo, Luísa Helena Perin de; Silva, Rodrigo Moreira da; Fonseca, Kátia da Silva; Cardoso, Jamille Mirelle de OliveiraSpecific chemotherapy using benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ tissue biodistribution in a murine model and its pharmacokinetic profile in plasma were monitored. A bioanalytical...
Higher expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 chemokines in the skin ...
Souza, Daniel Menezes; Cota, Renata Guerra de Sá; Carneiro, Cláudia Martins; Souza, Juliana Vitoriano de; Giunchetti, Rodolfo CordeiroBackground: The immune response in the skin of dogs infected with Leishmania infantum is poorly understood, and limited studies have described the immunopathological profile with regard to distinct levels of tissue parasitism and the clinical progression of canine visceral leishmaniasis (CVL). Methodology/Principal Findings: A detailed analysis of inflammatory cells (neutrophils, eosinophils, mast cells, lympho...