5 documents found, page 1 of 1
MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bil...
Duwe, Lea; Munoz-Garrido, Patricia; Lewinska, Monika; Lafuente-Barquero, Juan; Satriano, Letizia; Høgdall, Dan; Taranta, Andrzej; Nielsen, Boye S.Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcriptional output. We aimed to characterise miRNome dysregulation in CCA, including its impact on transcriptome homeostasis and cell behaviour. Methods: Small RNA seq...
Pancreatic Cancer Biomarkers: Oncogenic Mutations, Tissue and Liquid Biopsies, ...
Amaral, Maria João; Oliveira, Rui C.; Donato, Paulo; Tralhão, José GuilhermePancreatic cancer is one of the most fatal malignancies, as approximately 80% of patients are at advanced stages by the time of diagnosis. The main reason for the poor overall survival is late diagnosis that is partially due to the lack of tools for early-stage detection. In addition, there are several challenges in evaluating response to treatment and predicting prognosis. In this article, we do a review of th...
The role of mouse models in colorectal cancer research-The need and the importa...
Oliveira, Rui C.; Abrantes, Ana Margarida; Tralhão, José Guilherme; Botelho, Maria FilomenaColorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, ...
Revisiting Clinical Autopsies: Lessons to be Taken from the COVID-19 Pandemic
Almeida, Rui; Oliveira, Rui C.
Locational strategy for urban developments: costs analysis
Tavares, Luís Valadares; Oliveira, Rui C.The analysis of housing costs for new urban developments as a function of their sites is an essential step to evaluate alternative locational strategies and to optimize decisions in Urban and Regional Planning. The purpose of this study is developing a methodology of data collection, information processing, costs analysis and iterative search in order to select the sites for new urban developments within a give...