16 documents found, page 1 of 2
HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...
Andrade, Rita; Perez-Rojas, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C; Frazão, Laura P; Peixoto, CarolinaBackground/objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable access to care. This study aims to enhance pa...
HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...
Andrade, Rita; Pérez, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C.; Frazão, Laura P.; Peixoto, Carolina; Cubells, AlmudenaPublisher Copyright: © 2025 by the authors.; Background/Objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable ...
Clinical Impact of Preoperative Biliary Drainage in Patients with Ductal Adenoc...
Amaral, Maria João; Freitas, João; Amaral, Mariana; Serôdio, Marco; Oliveira, Rui Caetano; Donato, Paulo; Tralhão, José GuilhermeOur aim was to study the association between preoperative biliary drainage (PBD) and morbidity following cephalic pancreaticoduodenectomy (CPD) for pancreatic ductal adenocarcinoma (PDAC) and its prognostic impact, which is still controversial in the literature. A retrospective study was conducted, which included 128 patients who underwent CPD for PDAC, divided into two groups: those who underwent PBD (group 1)...
Tumor Stroma Area and Other Prognostic Factors in Pancreatic Ductal Adenocarcin...
Amaral, Maria João; Amaral, Mariana; Freitas, João; Oliveira, Rui Caetano; Serôdio, Marco; Cipriano, Maria Augusta; Tralhão, José GuilhermePancreatic ductal adenocarcinoma (PDAC) has a dense stroma, responsible for up to 80% of its volume. The amount of stroma can be associated with prognosis, although there are discrepancies regarding its concrete impact. The aim of this work was to study prognostic factors for PDAC patients submitted to surgery, including the prognostic impact of the tumor stroma area (TSA). A retrospective study with PDAC patie...
Innate Immune Cells in the Tumor Microenvironment of Liver Metastasis from Colo...
Sampaio-Ribeiro, Gabriela; Ruivo, Ana; Silva, Ana; Santos, Ana Lúcia; Oliveira, Rui Caetano; Gama, João; Cipriano, Maria AugustaColorectal cancer (CRC) is the third most prevalent type of cancer, and liver metastasis is the most common site of metastatic development. In the tumor microenvironment (TME), various innate immune cells are known to influence cancer progression and metastasis occurrence. CD274 (PD-L1) and CD206 (MRC1) are proteins that have been associated with poor prognosis and disease progression. We conducted a study on t...
Digital pathology implementation in a private laboratory: The CEDAP experience
Ferreira, Inês; Montenegro, Carlos Sachica; Coelho, Daniel; Pereira, Maria; da Mata, Sara; Carvalho, Sofia; Araújo, Ana Catarina; Abrantes, CarlosIntroduction: The transition to digital pathology has been carried out by several laboratories across the globe, with some cases described in Portugal. In this article,we describe the transition to digital pathology in a high-volume private laboratory, considering the main challenges and opportunities. Material and methods: Our process started in 2020, with laboratory workflow adaptation and we are currently us...
Clinical and Pathological Features of Double-Hit and Triple-Hit High-Grade B-Ce...
Almeida, Rui; Abrantes, Carlos; Gigliano, Davide; Oliveira, Rui Caetano; Teixeira, Paulo; Viegas, Marta; Rodrigues, Ângelo; Julião, Maria JoséBackground: High-grade B-cell lymphoma (HGBL) with rearrangements of MYC and BCL2 and/or BCL6, called double and triple-hit lymphomas (DTH-HGBL), are lymphoid malignancies with inferior outcomes when treated with standard chemotherapy. The identification of DTH-HGBL cases is challenging, considering their variable clinical, morphologic, and immunohistochemical features. Materials and Methods: Retrospective revi...
Envolvimento Pancreático por Mieloma Múltiplo: Um Caso Clínico de Icterícia Obs...
dos Santos Oliveira, Tiago; Ferrão Mendes, Vasco; Antunes, Célia; Oliveira, Carlos; Oliveira, Rui Caetano; Donato, PauloOs plasmocitomas extramedulares são tumores raros que podem ocorrer como lesões primárias (tumores primários) ou como uma manifestação de mieloma múltiplo (tumores secundários). O envolvimento pancreático por mieloma é muito raro (menos de 0,1% das massas pancreáticas). Os achados imagiológicos são inespecíficos. Na TC o achado mais típico consiste na presença de uma massa focal multilobulada, com realce homogé...
De novo colorectal cancer after liver and kidney transplantation–Microenvironme...
Oliveira, Rui Caetano; Silva, Edgar Tavares da; Abrantes, Ana Margarida; Antunes, Hugo; Teixeira, Paulo; Gomes, Ana; Martins, Ricardo; Furtado, EmanuelColorectal cancer (CRC) is a major health burden and may arise as a complication of solid organ transplantation. Our study aimed to assess the incidence of the CRC in kidney and liver transplanted patients at a tertiary and reference center and to describe their clinical and pathological features. Twelve patients, 10 men and two women, with a mean age of 60 years, composed our cohort, ten of them submitted to C...
Prognostic Factors After Hepatectomy for Gastric Adenocarcinoma Liver Metastase...
Temido, Maria José; Oliveira, Rui Caetano; Martins, Ricardo; Serôdio, Marco; Costa, Beatriz; Carvalho, César; Santos, Eva; Ferreira, LuísPurpose: Hepatectomy (Hp) is an alternative approach for the treatment of gastric carcinoma liver metastases (GCLM). However, prognostic factors that may assist patient selection are still controversial. Several pathologic features, such as the growth pattern (GP), associated with prognosis in colorectal cancer liver metastases, were never investigated in GCLM. Our principal aim was to assess if the GP has prog...