51 documents found, page 1 of 6
Symptom Clusters in Patients With Advanced Cancer: a Prospective Longitudinal C...
Simão, D; Barata, P; Alves, M; Papoila, AL; Oliveira, S; Lawlor, PThis study's purpose was to assess symptom cluster (SC) stability during disease progression and determine their strength of association with survival in patients with advanced cancer . Consecutively eligible patients with advanced cancer not receiving cancer-specific treatment and referred to a Tertiary Palliative Care Clinic were enrolled in a prospective cohort study. At first consultation (D0) and in subseq...
What Has Changed During the COVID-19 Pandemic? - The Effect on an Academic Brea...
Simão, D; Sardinha, M; Reis, AF; Spencer, AS; Luz, R; Oliveira, SIntroduction: One year ago, Portugal entered its first lockdown because of the coronavirus disease-2019 (COVID-19) pandemic. The impact of this on delays in cancer diagnosis and treatment is a major concern, which may negatively affect the outcomes of these patients. Materials and methods: This retrospective, single-center analysis compared the clinical and pathological characteristics of breast cancer (BC) pat...
Simulating the effects of mobility restrictions in the spread of SARS-CoV-2 in ...
Oliveira, S; Ribeiro, AI; Nogueira, P; Rocha, JCommuting flows and long-distance travel are important spreading factors of viruses and particularly airborne ones. Therefore, it is relevant to examine the association among diverse mobility scenarios and the spatial dissemination of SARS-CoV-2 cases. We intended to analyze the patterns of virus spreading linked to different mobility scenarios, in order to better comprehend the effect of the lockdown measures,...
Angiogenesis in the Normal Adrenal Fetal Cortex and Adrenocortical Tumors
Pereira, SS; Oliveira, S; Monteiro, M; Pignatelli, DSimple Summary Pharmacological angiogenesis modulation was robustly demonstrated to be a powerful clinical resource in oncotherapy. Adrenocortical carcinomas (ACC) often have a poor prognosis for which therapeutic options are limited. Understanding the mechanisms that regulate adrenocortical angiogenesis both under physiological conditions and in ACC could provide important clues on how these processes could be...
Connective tissue disease-associated interstitial lung disease
Oliveira, RP; Ribeiro, R; Melo, L; Grima, B; Oliveira, S; Alves, JDBACKGROUND: Connective tissue diseases (CTD) are frequently associated with interstitial lung disease (ILD), significantly impacting their morbidity and mortality. AIM: Analyze the experience of an autoimmune specialized unit on treating CTD-ILD and characterize the population based on most frequent diseases, imaging patterns, lung function tests results, serology and treatment. Assess mortality and mortality p...
Bioactive properties of phenolic compounds in physalis fruits
Guiné, Raquel P. F.; Oliveira, S; Correia, P.M.R.; Gonçalves, F.J.A.Physalis or cape gooseberry (Physalis peruviana L.) is believed to be rich in phenolic compounds, which are synthesized in plant tissues as a response to stress, and many of these compounds have biological properties with putative health benefits. The present work intended to study some bioactive properties of physalis related to the total phenolic compounds content and antioxidant activity, as well as their bi...
Nucleolin-sle a glycoforms as E-selectin ligands and potentially targetable bio...
Fernandes, E; Freitas, R; Ferreira, D; Soares, J; Azevedo, R; Gaiteiro, C; Peixoto, A; Oliveira, S; Cotton, S; Relvas-Santos, M; Afonso, LP; Palmeira, CBackground: Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis and efficient therapeutic targeting. Sialyl-Lewis A (SLeA), a terminal glycoepitope of glycoproteins and glycolipids, offers tremendous potential towards this objective. It is rarely expressed in healthy tissues and blood cells, whi...
Amiodarone-Induced Thyrotoxicosis in a Pediatric Patient: A Rare and Demanding ...
Oliveira, S; Marques, B; Laranjo, S; Lopes, LThyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating betw...
Overactive bladder symptom bother and health-related quality of life in patient...
Silva, R; Romão, V; Neves, M; Garcia, R; Oliveira, S; Brites, J, et al.The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS). METHODS: We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL a...
Cardiotoxicity in Breast Cancer Treatment: What About Left Ventricular Diastoli...
Timóteo, AT; Branco, LM; Filipe, F; Galrinho, A; Rio, P; Portugal, G; Oliveira, S; Cruz Ferreira, RAims: Cardiotoxicity is a possible complication of cancer treatment, particularly with anthracyclines and anti-HER2 drugs. Systolic dysfunction has already been described. Diastolic dysfunction and left atrial function are less studied. We sought to analyze the impact of cardiotoxic treatments on left ventricular diastolic function and left atrial (LA) function. Methods and results: Retrospective study of 100 p...