4 documents found, page 1 of 1
Serotonergic signaling modulation as a therapeutic strategy for Machado-Joseph ...
Oliveira, Stéphanie PereiraA doença de Machado-Joseph (DMJ) é uma doença autossómica dominante incurável, de início tardio. Caracteriza-se por uma expansão de repetições do tripleto CAG no gene MJD1/ATXN3, que origina proteínas com conformação nativa alterada, promovendo agregação e perda neuronal. É uma doença incapacitante, tendo grande impacto económico e social, sendo urgente o desenvolvimento de terapias. Nesta tese, procurámos estu...
Preclinical Evidence Supporting Early Initiation of Citalopram Treatment in Mac...
Esteves, Sofia; Oliveira, Stéphanie Pereira; Silva, Sara Carina Duarte; Cunha-Garcia, Daniela; Castro, Andreia Cristiana Teixeira; Maciel, P.Spinocerebellar ataxias are dominantly inherited neurodegenerative disorders with no disease-modifying treatment. We previously identified the selective serotonin reuptake inhibitor citalopram as a safe and effective drug to be repurposed for Machado-Joseph disease. Pre-symptomatic treatment of transgenic (CMVMJD135) mice strikingly ameliorated mutant ataxin-3 (ATXN3) pathogenesis. Here, we asked whether citalo...
Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in an...
Castro, Andreia Cristiana Teixeira; Sousa, Ana Luísa Jales Monteiro; Esteves, Sofia; Santos, Liliana da Silva; Fernandes, Anabela SilvaPolyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin reuptake inhibitor, in a small molecule screen of FDA-approved drugs that rescued neuronal dysfunction and red...
Study of the role of ceramide in acetate-induced cell death in colorectal carci...
Oliveira, Stéphanie PereiraColorectal carcinoma (CRC) has one of the highest incidences and mortality on the modern society, but a growing impact on less developed and economically transitioning nations. Prevention, surgery and radio/chemotherapy are the principal approaches to overcome the disease. Finding new efficient/specific treatments in CRC, better tolerated by patients is mandatory. News strategies to be used against colorectal c...