3 documents found, page 1 of 1
Relationships between diurnal adrenocortical activity, children’s attachment se...
Roque, Lisa; Veríssimo, Manuela; Oliveira, Tania F.; Fernandes, Marília; Rebelo, Ana; Oliveira, Rui F.This study investigated the relationship between diurnal adrenocortical activity and attachment quality (children’s secure base behaviours and mothers’ attachment representations). Forty-two children ranging in age from 18 to 26 months of age and their mothers participated in this study. Children and mothers’ saliva samples were collected on two consecutive days (Saturday and Sunday), three times per day: awake...
The efficiency of C-4 substituents in activating the beta-lactam scaffold towar...
Mulchande, Jalmira; Martins, Luisa; Moreira, Rui; Archer, Margarida; Oliveira, Tania F.; Iley, JimThe presence of a leaving group at C- 4 of monobactams is usually considered to be a requirement for mechanism- based inhibition of human leukocyte elastase by these acylating agents. We report that second- order rate constants for the alkaline hydrolysis and elastase inactivation by N- carbamoyl monobactams are independent of the pK(a) of the leaving group at C- 4. Indeed, the effect exerted by these substitue...
Crystallization and preliminary diffraction studies of porcine pancreatic elast...
Oliveira, Tania F.; Mulchande, Jalmira; Moreira, Rui; Iley, Jim; Archer, MargaridaPorcine pancreatic elastase (PPE) was crystallized in complex with a novel inhibitor at pH 5 and X-ray diffraction data were collected at a synchrotron source to 1.66 angstrom. Crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a = 50.25 angstrom, b = 57.94 angstrom and c = 74.69 angstrom. PPE is often used as model for drug target, due to its structural homology with the i...