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Antiviral activity and chemical characterization of Cissus erosa (Vitaceae) eth...
Reis,Adriana Cotta Cardoso; Moura,Hélia Maria Marques de; Silva,Breno Mello; Oliveira,Alaíde Braga de; Brandão,Geraldo CélioAbstract Cissus erosa (Vitaceae), popularly known in Brazil as Cipó-fogo, is a medicinal plant used in the treatment of warts and external ulcers. The present study aimed to evaluate the activity of stems and leaves ethanol extracts of C. erosa against the Dengue and Zika virus by the MTT colorimetric method and to carry on the phytochemical characterization of active extracts by high performance liquid chromat...
Antiviral activities of plants occurring in the state of Minas Gerais, Brazil: ...
Brandão,Geraldo Célio; Kroon,Erna G.; Santos,João Rodrigues dos; Stehmann,João Renato; Lombardi,Júlio A.; Oliveira,Alaíde Braga deEthanol extracts of eighteen Bignoniaceae species have been evaluated by the MTT assay for cytotoxicity in Vero cells and for antiviral activity against Human herpes virus type 1, Vaccinia virus and murine Encephalomyocarditis virus. Among such species, seven are reported to be of traditional medicinal use No cytotoxicity was observed for most of the extracts up to the concentration of 500 μg/mL. Fourteen (50%)...
Anatomia e histoquímica dos órgãos vegetativos de Polygonum hydropiperoides Mic...
Lopes,Daniela E. Silva; Oliveira,Virgínia Del Carmen; Macedo,João F.; Oliveira,Alaíde Braga de; Jácome,Rose Lisieux R. PaivaPolygonum hydropiperoides Michaux é uma espécie conhecida popularmente como "erva-de-bicho", amplamente utilizada na medicina tradicional como anti-hemorroidal, antiinflamatória e antidiarréica. O presente trabalho tem como objetivo a caracterização anatômica e histoquímica da folha, caule e raiz, que constituem a droga vegetal, visando estabelecer parâmetros para o controle de qualidade. O material vegetal foi...
Antimicrobial activity of Trembleya laniflora , Xyris platystachia and Xyris pt...
Ventura,Claiton Pires; Oliveira,Alaíde Braga de; Braga,Fernão CastroTrembleya laniflora (D. Don) Cogn. (Melastomataceae), Xyris platystachia Alb. Nilss. (Xyridaceae) and Xyris pterygoblephara Kunth., Brazilian species collected from a biodiversity hotspot for conservation priority, had their antimicrobial activity evaluated against standardized strains of Staphylococcus aureus and Micrococcus luteus, by the agar diffusion assay. All extracts, assayed in the concentration of 200...
Estudo de modelagem molecular de complexos ferriprotoporfirina-IX e quinolinoca...
Silva,Thais Horta Álvares da; Oliveira,Marcelo Tavares de; Santos,Hélio Ferreira dos; Oliveira,Alaíde Braga de; De Almeida,Wagner BatistaQuinine and quinidine are well-known 4-quinolinecarbinolamines that exhibit antimalarial activity, but, in contrast, their epimers 9-epiquinine and 9-epiquinidine are almost inactive. Literature data are conflicting in describing the 4-quinolinecarbinolamine interaction mode with the molecular target, the ferriprotoporphyrin IX [Fe(III)PPIX]. In the present paper, a pharmacophore is proposed based on the bindin...
Estudo químico e perfil cromatográfico das cascas de Aspidosperma parvifolium A...
Jácome,Rose Lisieux R. Paiva; Oliveira,Alaíde Braga de; Raslan,Délio S.; Wagner,HildebertFour known alkaloids, uleine, epiuleine, apparicine and desmethyluleine, besides the isoprenoids lupeol and stigmasterol were isolated from the stem bark of Aspidosperma parvifolium. Their identification was based on spectroscopic analysis (UV, IR, ¹H-NMR, 13C-NMR, MS). The chromatographic profile of the ethanolic extract was obtained by HPLC and uleine, epiuleine and apparicine were identified in the extract.
Optimization of diterpenes bioconversion process by the fungus Cephalosporium a...
Takahashi,Jacqueline Aparecida; Barroso,Henrique de Almeida; Oliveira,Alaíde Braga deParameters for a more efficient biotransformation of diterpene-like compounds by the fungus Cephalosporium aphidicola were established by carrying out microscale feedings at several conditions. Experiments were guided by thin layer chromatography and gas chromatography analysis. It was observed that the substrate should be added in ethanol at concentrations between 15 to 30 mg per 100 ml of medium. The extracti...
Análise de naftoquinonas em extratos brutos de raízes de Zeyheria montana M. (b...
Jácome,Rose Lisieux. R. Paiva; Oliveira,Alaíde Braga de; Raslan,Délio S.; Müller,Andreas; Wagner,HildebertFour naphthoquinones, lapachol, a-lapachone, dehydro-a-lapachone and 4-hydroxy-a-lapachone were isolated from the ethanol extract of Zeyheria montana M. roots (Bignoniaceae) and were identified by spectroscopic methods. These naphthoquinones, except 4-hydroxy-a-lapachone, were quantified by HPLC, in the crude ethanol extracts of Z. montana roots. The separation of lapachol, a-lapachone and dehydro-a-lapachone w...
Avaliação quantitativa de cardenolídeos no cultivar experimental de Digitalis l...
Braga,Fernão Castro; Kreis,Wolfgang; Récio,Rubens Almeida; Oliveira,Alaíde Braga deThe content of digoxin and lanatoside C (jointly quantified), lanatoside A, lanatoside B, glucoevatromonoside, odorobioside G, glucogitoroside, glucoverodoxine, glucodigifucoside and digitalinum verum was determined by HPLC in Digitalis lanata harvested in Brazil, as well as in clones industrially employed for the production of cardenolides. The Brazilian plants presented greater variation in the contents of ca...
Atividade moluscicida da mistura de ácidos 6-n-alquil salicílicos (ácido anacár...
Mendes,Nelymar Martineli; Oliveira,Alaíde Braga de; Guimarães,João Edmundo; Pereira,José Pedro; Katz,NaftaleFoi comparada, em laboratório, a atividade moluscicida do extrato hexânico da casca da castanha do caju - Anacardium occidentalel L. (EHCCC), do complexo de cobre (II), docomplexo de chumbo (II) e do ácido anacárdico com objetivo de encontrar entre eles um produto que apresentasse maior estabilidade que o ácido anacárdico. Este foi preparado tratando o EHCCC com hidróxido de chumbo (II) ou com o sulfato de cobr...