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Flavonoides e atividade antioxidante em Palicourea rigida Kunth, Rubiaceae
Rosa,Elisa A. da; Silva,Beatriz C. e; Silva,Francielly M. da; Tanaka,Clara M. A.; Peralta,Rosane M.; Oliveira,Cecília M. A. de; Kato,LucíliaA atividade antioxidante, avaliada pelo método DPPH (1,1-difenil-2-picrilidrazila), e o teor em compostos fenólicos totais do extrato bruto metanólico e frações das folhas da espécie Palicourea rigida Kunth, Rubiaceae, foram quantificadas neste trabalho. Apesar da baixa atividade apresentada pelo extrato bruto (500 ppm), a fração acetato de etila apresentou atividade moderada (192 ppm) e o maior teor de fenólic...
Abietatrienes diterpenoids from Sagittaria montevidensis SSP Montevidensis
Tanaka,Clara M. A.; Radke,Vanessa S. C. O.; Silva,Cleuza C. da; Nakamura,Celso V.; Oliveira,Pollyanna L. de; Kato,Lucilia; Oliveira,Cecília M. A. deThe antimicrobial properties of the hexane, hexane/EtOAc and methanol fractions of the fresh petioles of Sagittaria montevidensis ssp montevidensis (Alismataceae) were evaluated against fungi and Gram-negative and Gram-positive bacteria. A new abietatriene-type diterpenoid, 3β,7α-dihydroxi-abieta-8,11,13-triene and the known 3β-hydroxy-abieta-8,11,13-trien-7-one were isolated from the most active fraction teste...
Atividade antiproliferativa de Sloanea garckeana K. Schum.
Romero,Adriano Lopes; Fontana,Álvaro; Silva,Cleuza Conceição da; Souza,Maria Conceição de; Carvalho,João Ernesto de; Faria,Emiret O.; Kato,LuciliaThe crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC5...
Abietane diterpenes from Sagittaria montevidensis ssp montevidensis Charm. &...
Radke,Vanessa S. C. de O.; Amaral,Maria do Carmo E.; Schuquel,Ivânia T. A.; Silva,Cleuza C. da; Oliveira,Cecília M. A. de; Tanaka,Clara M. A.Two new abietane-type diterpenes, 3beta-hydroxy-9alpha, 13alpha-epidioxyabiet-8(14)-ene (1) and 3-oxo-9alpha,13alpha-epidioxyabiet-8(14)-ene (2), were isolated from the methanolic crude extract of the petioles of Sagittaria montevidensis ssp montevidensis (Alismataceae). The structures of 1 and 2 were determined on the basis of spectrometric analyses including HREIMS, IR as well as ¹H and 13C 1 and 2D NMR.
Chemical composition and antifungal activity of the essential oil of Hyptis ova...
Oliveira,Cecília M. A. de; Silva,Maria do Rosário R.; Kato,Lucília; Silva,Cleuza C. da; Ferreira,Heleno D.; Souza,Lúcia K. H.The leaves of Hyptis ovalifolia Benth. (Lamiaceae) were subjected to hydrodistillation and the resulting volatiles were investigated by GC/MS. The main constituent representing 60% of the essential oil was isolated by column chromatography and identified by spectroscopic methods as (R)-6-[(Z)-1-heptenyl]-5,6-dihydro-2H-pyran-2-one (1). This compound showed strong in vitro activity against four dermatophyte fung...