2 documents found, page 1 of 1
Effect of N-acetylcysteine in hearts of rats submitted to controlled hemorrhagi...
Oliveira Filho,Luiz Dantas de; Saad,Karen Ruggeri; Saad,Paulo Fernandes; Koike,Marcia Kiyomi; Silva,Sônia Maria da; Montero,Edna Frasson de SouzaAbstractIntroduction:Pharmacological therapy is a strategy for the prevention of complications associated with ischemia and reperfusion injury that occurs after volume replacement in the treatment of hemorrhagic shock.Objective:The aim of this study was to evaluate the effect of N-acetylcysteine associated with fluid resuscitation in cardiac injury in a rat hemorrhagic shock model.Methods:Mice Wister male rats ...
Effect of N-acetylcysteine on pulmonary cell death in a controlled hemorrhagic ...
Saad,Paulo Fernandes; Saad,Karen Ruggeri; Oliveira Filho,Luiz Dantas de; Ferreira,Sueli Gomes; Koike,Marcia Kiyomi; Montero,Edna Frasson de SouzaPURPOSE: To evaluate the effect of N-acetylcysteine (NAC) combined with fluid resuscitation on pulmonary cell death in rats induced with controlled hemorrhagic shock (HS). METHODS: Two arteries (MAP calculation and exsanguination) and one vein (treatments) were catheterized in 22 anesthetized rats. Two groups of male albino rats were induced with controlled HS at 35mmHg MAP for 60 min. After this period, the RL...