7 documents found, page 1 of 1
Faster cryptococcus melanization increases virulence in experimental and human ...
Sousa, Herdson Renney de; Oliveira Júnior, Getúlio Pereira de; Frazão, Stefânia de Oliveira; Gorgonha, Kaio César de Melo; Rosa, Camila PereiraCryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neofo...
Cryptococcal virulence in humans : learning from translational studies with cli...
Sousa, Herdson Renney de; Frazão, Stefânia de Oliveira; Oliveira Júnior, Getúlio Pereira de; Albuquerque, Patrícia; Nicola, André MoraesCryptococcosis, an invasive mycosis caused by Cryptococcus spp, kills between 20% and 70% of the patients who develop it. There are no vaccines for prevention, and treatment is based on a limited number of antifungals. Studying fungal virulence and how the host responds to infection could lead to new therapies, improving outcomes for patients. The biggest challenge, however, is that experimental cryptococcosis ...
Transcriptional remodeling patterns in murine dendritic cells infected with Par...
Silva, Calliandra Maria de Souza; Hurtado, Fabián Andrés; Tavares, Aldo Henrique Fonseca Pacheco; Oliveira Júnior, Getúlio Pereira de; Raiol, TaináMost people infected with the fungus Paracoccidioides spp. do not get sick, but approximately 5% develop paracoccidioidomycosis. Understanding how host immunity determinants influence disease development could lead to novel preventative or therapeutic strategies; hence, we used two mouse strains that are resistant (A/J) or susceptible (B10.A) to P. brasiliensis to study how dendritic cells (DCs) respond to the ...
Laccase affects the rate of Cryptococcus neoformans nonlytic exocytosis from ma...
Frazão, Stefânia de Oliveira; Sousa, Herdson Renney de; Silva, Lenise Gonçalves da; Folha, Jéssica dos Santos; Gorgonha, Kaio César de MeloNonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages and ameboid predators. Despite a great amount of research dedicated to unraveling this process, t...
Estudos de métodos alternativos para o controle da vassoura-de-bruxa
Oliveira Júnior, Getúlio Pereira deSubmitted by Maria José Martins (mmartins@ucb.br) on 2019-07-19T17:15:42Z No. of bitstreams: 1 GetúlioOliveiraJrTCCGraduacao2010.pdf: 923554 bytes, checksum: bb4d49e9de9defd20ab4590e1fb03307 (MD5); Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2019-07-23T19:58:36Z (GMT) No. of bitstreams: 1 GetúlioOliveiraJrTCCGraduacao2010.pdf: 923554 bytes, checksum: bb4d49e9de9defd20ab4590e1fb03307...
Investigação de vesículas extracelulares em animais submetidos a exercício físi...
Oliveira Júnior, Getúlio Pereira deTese (doutorado) — Universidade de Brasília, Faculdade de Medicina, Pós-Graduação em Patologia Molecular, 2016.; As vesículas extracelulares (VEs) são liberadas pelas células e circulam em fluidos biológicos. Elas carregam e entregam proteínas, lipídeos e ácidos nucleicos que participam da regulação da expressão gênica na célula receptora. Entre os ácidos nucleicos transportados por VEs estão os microRNAs (miRN...
Análise de microRNAs músculo específicos em frações plasmáticas antes e após co...
Oliveira Júnior, Getúlio Pereira deDissertação (mestrado)—Universidade de Brasília, Instituto de Biologia, Programa de Pós-Graduação em Patologia Molecular, 2012.; O papel do exercício físico de endurance é bem estabelecido na promoção da saúde e proteção contra doenças, principalmente aquelas associadas ao sistema cardiovascular. No entanto, são pouco conhecidos os mecanismos moleculares relacionados a esta importante atividade física para a sa...