5 documents found, page 1 of 1
Effect of atenolol pre-treatment in heart damage in a model of intestinal ische...
Okada,Mieko; Falcão,Luiz Fernando Reis; Ferez,David; Martins,José Luiz; Errante,Paolo Ruggero; Rodrigues,Francisco Sandro Menezes; Caricati-Neto,AfonsoAbstract Purpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n=8), anesthetized and divided in: Sham: submitted to operation only; group SS+IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and o...
A comparative study of pentoxifylline effects in adult and aged rats submitted ...
Ramallo,Bianca Trovello; Lourenço,Elizete; Cruz,Renata Harumi; Almeida,Jacqueline Camargo; Taha,Murched Omar; Silva,Priscilla Yuri Okochi AlvesPURPOSE: To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals. METHODS: Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid wa...
Ischemic preconditioning and the gene expression of enteric endothelial cell bi...
Taha,Murched Omar; Ferreira,Regiane Miranda; Taha,Nabiha Saadi Abrahão; Monteiro,Hugo Pequeno; Caricati-Neto,Afonso; Oliveira-Júnior,Itamar SouzaPURPOSE: To investigate the effects of ischemic preconditioning (IPC) on the expression of pro and anti-apoptotic genes in rat endothelial cells undergoing enteric ischemia (I) and reperfusion (R). METHODS: Thirty rats underwent clamping of the superior mesenteric vessels. Sham group (GS) laparotomy only; Ischemia (GI): intestinal ischemia (60 min); Ischemia and Reperfusion (GIR): ischemia (60 min) and reperfus...
Short courses of mechanical ventilation with high-O2 levels in elderly rat lungs
Cavassani,Sâmia Santos; Junqueira,Virginia Berlanga Campos; Moraes,Juliana Britto; Luzo,Karen Kristina; Silva,Claudeny Matos Assis; Barros,MacielPURPOSE: To evaluate the effects of mechanical ventilation (MV) of high-oxygen concentration in pulmonary dysfunction in adult and elderly rats. METHODS: Twenty-eight adult (A) and elderly (E), male rats were ventilated for 1 hour (G-AV1 and G-EV1) or for 3 hours (G-AV3 and G-EV3). A and E groups received a tidal volume of 7 mL/kg, a positive end-expiratory pressure of 5 cm H2O, respiratory rate of 70 cycles pe...
Pretreatment with pentoxifylline attenuates lung injury induced by intestinal i...
Marqui,Carlos Eduardo; Silva,Helga Cristina Almeida; Ferez,David; Cavassani,Sâmia Santos; Moraes,Juliana Britto; Silva,Danielle Aparecida Marino daPURPOSE: To investigate the protective effect of pentoxifylline against the lung injury observed after intestinal ischemia (I) followed by a period of reperfusion (R). METHODS: Twenty-eight male Wistar rats were equally divided into 4 experimental groups and operated under ketamine-xylazine anesthesia. (1) Sham: falsely-operated animals; (2) SS+IR: intestinal ischemia was accomplished by clipping the superior m...