52 documents found, page 1 of 6
Genetic variants in oxidative stress-related genes and their impact on prognosi...
Alves, Raquel; Ventura, Filipa; Jorge, Joana; Marques, Gilberto; Coucelo, Margarida; Diamond, Joana; Oliveiros, Bárbara; Pereira, AméliaChronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia characterized by the BCR::ABL1 fusion gene, which codifies the BCR-ABL protein with increased tyrosine kinase activity. Despite the clinical results for the outstanding tyrosine kinase inhibitors (TKIs), drug resistance is a problem in CML management. Genetic variants that alter redox homeostasis by changing antioxidant enzyme expression or...
Differentiating Factors of Clinical Trial Sites in Portugal
Oliveiros, Bárbara; Pimentel, Francisco; Brandão, Inês; Silva, SóniaClinical research is developing exponentially in Portugal. It provides patients with early access to innovative molecules, helping to improve healthcare provision, the life expectancy and quality of life of the Portuguese population. However, the number of clinical trials carried out in Portugal is significantly lower than in other countries of a similar size, and the full potential of the country has not yet b...
Effect of home-based exercise prehabilitation on postoperative outcomes in colo...
Machado, Pedro; Paixão, André; Oliveiros, Bárbara; Martins, Raul A.; Cruz, JoanaPurpose Home-based exercise training may improve access to surgical prehabilitation in colorectal cancer (CRC) patients, but its efficacy remains unclear. This study systematically investigated the effects of home-based exercise prehabilitation on postoperative exercise capacity, complications, length of hospital stay, and health-related quality of life (HRQoL) in CRC patients. Methods Randomized controlled tri...
Higher Metabolic Dysfunction in Adolescents Who Were Born Very Preterm: Case Co...
de Brito Chagas, Joana; Dinis, Isabel; Oliveiros, Bárbara; Mimoso, Gabriela; Morais, SofiaIntroduction: Literature has shown an increase in cardiovascular risk and metabolic changes in adolescents and young adults who were born preterm. In this regard, the present study aimed to assess metabolic dysfunction in adolescents who were born at less than 32 weeks of gestational age. Methods: This case-control study was performed on adolescents within the age range of 10-17 years and born in a level III ma...
Bulk-Fill Resins versus Conventional Resins: An Umbrella Review
Silva, Gonçalo; Marto, Carlos Miguel; Amaro, Inês; Coelho, Ana; Sousa, José Paulo; Ferreira, Manuel Marques; Francisco, InêsCurrently, composite resins have become the material of choice for the restoration of posterior teeth. Although bulk-fill resins represent a tempting alternative due to their lower complexity and faster use, some dentists are reluctant to use this material. The objective is to compare the performance of bulk-fill resins and conventional resins in direct restorations of posterior teeth based on the literature. T...
Ostial vs. wide area circumferential ablation guided by the Ablation Index in p...
Sousa, Pedro A.; Barra, Sérgio; Saleiro, Carolina; Khoueiry, Ziad; Adão, Luís; Primo, João; Lagrange, Philippe; Lebreiro, Ana; Fonseca, PauloPulmonary vein isolation (PVI) guided by the Ablation Index (AI) has shown high acute and mid-term efficacy in the treatment of paroxysmal atrial fibrillation (AF). Previous data before the AI-era had suggested that wide-area circumferential ablation (WACA) was preferable to ostial ablation. However, with the use of AI, we hypothesize that ostial circumferential ablation is non-inferior to WACA and can improve ...
Home-Based Preoperative Exercise Training for Lung Cancer Patients Undergoing S...
Machado, Pedro; Pimenta, Sara; Garcia, Ana Luís; Nogueira, Tiago; Silva, Sónia; Oliveiros, Bárbara; Martins, Raul A.; Cruz, JoanaBackground: Clinical guidelines recommend prehabilitation with exercise training to optimize recovery after lung cancer surgery. However, the lack of access to facility-based exercise programs is a major barrier to routine participation. This study aimed to assess the feasibility of a home-based exercise intervention before lung cancer resection. Methods: We conducted a prospective, two-site feasibility study, ...
Effectiveness of Intra-Arterial Chemotherapy for the Treatment of Intraocular R...
Castela, Guilherme; Providência, Joana; Monteiro, Madalena; Oliveiros, Bárbara; Silva, Sónia; Brito, Manuel; Machado, Egídio; Murta, Joaquim NetoPurpose: We aim to report about effectiveness and safety in the context of our centers’ setting in the management of retinoblastoma with intra-arterial chemotherapy (IAC) in a 5-year retrospective analysis of the Portuguese population. Patients and Methods: Retrospective analysis of consecutive cases of retinoblastoma selected to initiate IAC between 2015 and 2020, at the Portuguese National Reference Center. A...
Is hybrid therapy more efficient in the eradication of Helicobacter pylori infe...
Temido, Maria José; Mbanze, Dara; Almeida, Nuno; Oliveiros, Bárbara; Gravito-Soares, Elisa; Figueiredo, PedroIntroduction Hybrid therapy (HT) is a non-bismuth quadruple therapy created to surpass Helicobacter pylori’s (H. pylori) resistance rates to antibiotics. HT has excellent eradication rates, as well as a very good compliance and safety profile. We aim to compare HT with sequential therapy (ST) and concomitant therapy (CT) for the eradication of H. pylori. Methods This systematic review was conducted following th...
Myopia control: short-term effect of 0.01% atropine vs. defocus incorporated mu...
Guimarães, Sandra; Barros da Silva, Patrícia; Oliveiros, Bárbara; Silva, EduardoPurpose To compare 0.01% atropine with DIMS spectacle lenses in the prevention of myopia progression in European children. Methods This was a retrospective study including data from pediatric European patients with myopia. From November 2021 to March 2022, only 0.01% atropine was prescribed because DIMS lenses were still not available in Portugal. From March to October 2022, only DIMS spectacle lenses were pres...