15 documents found, page 1 of 2

l-proline supplementation improves nitric oxide bioavailability and counteracts...

We evaluated whether l-proline (Pro) supplementation improves redox status and nitric oxide (NO) bioavailability and prevents or delays angiotensin II (AngII)-induced hypertension. Male Sprague-Dawley rats were distributed to four experimental groups: Pro + AngII (Pro-Ang), Pro + Saline (Pro-Sal), Vehicle + AngII (Veh-Ang) and Veh + Saline (Veh-Sal). Pro solution (2 g.kg-1·day-1) or water (vehicle) were orally ...

Adenosine A2A receptors modulate α-Synuclein aggregation and toxicity

Abnormal accumulation of aggregated α-synuclein (aSyn) is a hallmark of sporadic and familial Parkinson's disease (PD) and related synucleinopathies. Recent studies suggest a neuroprotective role of adenosine A2A receptor (A2AR) antagonists in PD. Nevertheless, the precise molecular mechanisms underlying this neuroprotection remain unclear. We assessed the impact of A2AR blockade or genetic deletion (A2AR KO) o...

Does strain influence pain perception profiles in streptozotocin-induced diabet...

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NADPH oxidase as a therapeutic target against neuropathic pain: evaluation of s...

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Does genetic background affect the development of streptozotocin-induced diabet...

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Evaluation of redox dysfunction in the spinal cord of rats at early stages of p...

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NADPH oxidase as a therapeutic target against neuropathic pain: a study in the ...

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Pain perception and NTS activation in hypertensive and normotensive rats with d...

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Hypertension and genetic background affect pain submodalities in streptozotocin...

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Impact of hypertension on painful diabetic neuropathy in streptozotocin-diabeti...