2 documents found, page 1 of 1
Current Evidence on the Impact of Medication Optimization or Pharmacological In...
Pazan, F; Petrovic, M; Cherubini, A; Onder, G; Cruz-Jentoft, A; Denkinger, M; van der Cammen, T; Stevenson, J; Ibrahim, K; Rajkumar, C; Bakken, MBackground: Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty. Methods: A literature search was performed in Medline to detect prospective randomized controlled trials (RCTs) testing the effects of pharmacological interventions or medication optimiza...
Immunological alterations in frail older adults: A cross sectional study
Valdiglesias, V; Marcos-Perez, D; Lorenzi, M; Onder, G; Gostner, JM; Strasser, B; Fuchs, D; Bonassi, SFrailty is a progressive physiologic decline in multiple body systems, characterized by loss of function, loss of physiologic reserve, and increased vulnerability to disease and death. This condition is induced by a complex and multifactorial interaction between genetic, biological, physical, psychological and environmental factors. To understand the interplay between the age-related decline of the immune respo...