4 documents found, page 1 of 1
Anti-inflammatory and redox-protective activities of citronellal
Melo, Mônica Santos de; Guimarães, Adriana Gibara; Santana, Michele Fraga de; Barreto, Rosana de Souza Siqueira; Lima, Amanda do Carmo Bion deThe anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. admi...
Bioassay-guided evaluation of central nervous system effects of citronellal in ...
Melo, Mônica Santos de; Souza, Marilia Trindade de Santana; Guimarães, Adriana Gibara; Barreto, Rosana de Souza SiqueiraThe central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to...
Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nocicepti...
Venâncio, Antônio Medeiros; Marchioro, Murilo; Estevam, Charles dos Santos; Melo, Mônica Santos de; Santana, Marília Trindade deThe present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- and capsaicin (2.5 µg)- induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separ...
Evaluation of adherence to treatment by patients seen in a psychosocial care ce...
Souza, Thaís Teles; Silva, Wellington Barros; Onofre, Alexandre Sherlley Casimiro; Quintans, Jullyana de Souza SiqueiraNo tratamento de desordens mentais, a não-adesão ao tratamento ocorre em cerca de 50% dos casos e é responsável por inúmeros prejuízos, além de ser a principal causa de morbidade psiquiátrica. O presente estudo objetivou avaliar a adesão ao tratamento medicamentoso de pacientes atendidos em um Centro de Atenção Psicossocial (CAPS) no Nordeste do Brasil. A avaliação da adesão ao tratamento foi feita através dos ...