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Pangenome graphs and their applications in biodiversity genomics

Secomandi, Simona; Gallo, Guido Roberto; Rossi, Riccardo; FERNANDES, CARLOS; Jarvis, Erich D.; Bonisoli-Alquati, Andrea; Gianfranceschi, Luca

Complete datasets of genetic variants are key to biodiversity genomic studies. Long-read sequencing technologies allow the routine assembly of highly contiguous, haplotype-resolved reference genomes. However, even when complete, reference genomes from a single individual may bias downstream analyses and fail to adequately represent genetic diversity within a population or species. Pangenome graphs assembled fro...


An integrated assessment of niche partitioning reveals mechanisms of coexistenc...

Barros, Ana Luisa; Raposo, Diogo; Almeida, João David; Jesus, Hugo; Oliveira, Maria Alexandra; FERNANDES, CARLOS; MacKenzie, Darryl I.

Species diversity depends on the capacity of species to coexist, and when these share similar ecological requirements some degree of partitioning of the ecological niche is expected. Within the order Carnivora, direct and indirect interspecific interactions shape community structure and composition. Although strong negative interactions (e.g., interspecific killing) are expected between large carnivores and sub...


A global initiative for ecological and evolutionary hologenomics

Leonard, Aoife; Abalos, Javier; Adhola, Titus; Aguirre, Windsor; Aizpurua, Ostaizka; Ali, Shahzad; Andreone, Franco; Aubret, Fabien

The Earth Hologenome Initiative (EHI) is a global collaboration to generate and analyse hologenomic data from wild animals and associated microorganisms using standardised methodologies underpinned by open and inclusive research principles. Initially focused on vertebrates, it aims to re-examine ecological and evolutionary questions by studying host–microbiota interactions from a systemic perspective.


Development of a Transmission-Based Open-Ended Coaxial-Probe Suitable for Axill...

Savazzi, Matteo; Porter, Emily; OHalloran, Martin; Costa, Jorge R.; FERNANDES, CARLOS; M. Felício, João; Conceicao, Raquel C.

We assess the feasibility of a transmission-based open-ended coaxial-probe for tissue dielectric properties estimation. The ultimate goal is to use it for axillary lymph node dielectric measurement, which is not trivial when applying the state-of-the-art reflection-based open-ended coaxial-probe. The proposed technique consists in placing the material under test between two opposite open-ended coaxial-probes an...


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