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The biological potential hidden in inclusion bodies
Gifre-Renom, L; Seras-Franzoso, J; Rafael, D; Andrade, F; Cano-Garrido, O; Martinez-Trucharte, F; Ugarte-Berzal, E; Martens, E; Boon, L; Villaverde, AInclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein delivery. Nevertheless, IBs have been, so far, exclusively sifted by their biological activity in vitro to be considered in further protein-based treatments in vivo. Matrix metalloproteinase-9 (MMP-9) protein, whic...
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto