4 documents found, page 1 of 1
Remodelling of the cardiac extracellular matrix proteome during chronological a...
Santinha, Deolinda; Vilaça, Andreia; Estronca, Luís; Schüler, Svenja; Bartoli, Catherine; Sandre-Giovannoli, Annachiara De; Figueiredo, Arnaldo
Extensive remodeling of the extracellular matrix during aging contributes to ag...
Schüler, Svenja C; Kirkpatrick, Joanna M; Schmidt, Manuel; Santinha, Deolinda; Koch, Philipp; Di Sanzo, Simone; Cirri, Emilio; Hemberg, MartinDuring aging, the regenerative capacity of skeletal muscle decreases due to intrinsic changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use quantitative mass spectrometry to characterize intrinsic changes in the MuSC proteome and remodeling of the MuSC niche during aging. We generate a network connecting age-affected ligands located in the niche and cell surface receptors on MuSCs. T...
Vulnerability of progeroid smooth muscle cells to biomechanical forces is media...
Pitrez, Patrícia R.; Estronca, Luís Miguel Beicinha Branco; Monteiro, Luís Miguel Marques; Colell, Guillem; Vazão, HelenaHutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-SMCs generated from induced pluripotent stem cells (iPSCs), to study their vulnerability to flow...
Vulnerability of progeroid smooth muscle cells to biomechanical forces is media...
Pitrez, Patricia R.; Estronca, Luís; Monteiro, Luís Miguel; Colell, Guillem; Vazão, Helena; Santinha, Deolinda; Harhouri, Karim; Thornton, DanielHutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-SMCs generated from induced pluripotent stem cells (iPSCs), to study their vulnerability to flow...