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Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neu...
Novo, João P.; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B; Malva, João O.; Fontes-Ribeiro, CarlosMethylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir, MeHg bioaccumulates along the food chain until it is consumed by riverine populations. There has been much interest in the neurotoxicity of MeHg due to recent environmental disasters. Studies have also addressed the implications of long-term MeHg exposure for humans. The central nervous system is particularly susceptible t...
Editorial: Interplay Between Nutrition, the Intestinal Microbiota and the Immun...
Oriá, Reinaldo B; Empadinhas, Nuno; Malva, João O.Santa Casa da Misericórdia de Lisboa—Mantero Belard Neurosciences Prize 2016 (MB-40-2016), FEDER-CENTRO 2020—CENTRO-01-0145-FEDER-000012 (HealthyAging 2020) and COMPETE and FCT (POCI-01-0145-FEDER- 029221 and UIDB/04539/2020), Pest-C/SAU/UI3282/2013-2014 and CNC.IBILI UID/NEU/04539/2013 with national funds PT2020/COMPETE 2020 and FCT/FUNCAP (POCTI-FEDER- 02/SAICT/2017/31699), Brazilian CAPES-PROCAD (071/2013 # ...
Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Per...
de Aquino, Cristhyane Costa; Leitão, Ricardo A.; Oliveira Alves, Luís A.; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F. M.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
Apolipoprotein E4 influences growth and cognitive responses to micronutrient su...
Mitter, Sumeet S; Oriá, Reinaldo B; Kvalsund, Michelle P; Pamplona, Paula; Joventino, Emanuella Silva; Mota, Rosa M. S.; Gonçalves, Davi COBJECTIVE: Apolipoprotein E4 may benefit children during early periods of life when the body is challenged by infection and nutritional decline. We examined whether apolipoprotein E4 affects intestinal barrier function, improving short-term growth and long-term cognitive outcomes in Brazilian shantytown children. METHODS: A total of 213 Brazilian shantytown children with below-median height-for-age z-scores (HA...