19 documents found, page 1 of 2
ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric ...
Oriá, Reinaldo B.; Freitas, Raul S.; Roque, Cássia R.; Nascimento, José Carlos R; Silva, Ana Paula; Malva, João O.; Guerrant, Richard L.Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the ...
The Transition From Undernutrition to Overnutrition Under Adverse Environments ...
Leocádio, Paola Caroline L.; Lopes, Synara C.; Dias, Ronaldo P.; Alvarez-Leite, Jacqueline I.; Guerrant, Richard L.; Malva, João O.; Oriá, Reinaldo B.Nutritional transition is an important public health issue in developing countries, where switch from undernutrition to overnutrition/obesity is rapidly occurring, often within two or three generations. Such transition is related to changes in lifestyle, with people having more access to western high-caloric diets. In developing countries, settings of poverty, poor sanitation and hygiene are still common, where...
Obesity: more than an inflammatory, an infectious disease?
Leocádio, Paola C. L.; Oriá, Reinaldo B.; Crespo-Lopez, Maria Elena; Alvarez-Leite, Jacqueline I.Much is discussed if obesity or diet components modify the “healthy” microbiota or if microbiota modifications trigger events that culminate in obesity. This association is probably reciprocal, and inflammation has crucial participation on it. We will discuss recent studies showing gut microbiome as an obesogenic factor and the mechanisms linked to the associated of diet, microbiota, and low-grade inflammation.
Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neur...
Pinto, Daniel V.; Raposo, Ramon S.; Matos, Gabriella A.; Alvarez-Leite, Jacqueline I.; Malva, João O.; Oriá, Reinaldo B.Mercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurot...
Effect of hypoproteic and high-fat diets on hippocampal blood-brain barrier per...
Aquino, Cristhyane Costa de; Leitão, Ricardo A.; Alves, Luis Antonio de Oliveira; Coelho-Santos, Vanessa; Guerrant, Richard L.; Ribeiro, Carlos F.Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
In the heart of the Amazon: noncommunicable diseases and apolipoprotein E4 geno...
Arrifano, Gabriela P. F.; Alvarez-Leite, Jacqueline I.; Souza-Monteiro, José Rogério; Augusto-Oliveira, Marcus; Paraense, Ricardo; Macchi, Barbarella M.The Amazon River basin is the largest tropical forest in the world. Most of the Amazon belongs to Brazil, a developing country that currently faces huge challenges related to the consolidation of its universal healthcare system. Noncommunicable diseases (NCDs) are the leading cause of death in Brazil, accounting for 74% of all deaths, and NCDs are probably underestimated in Amazonian population because of their...
Modulation of intestinal immune and barrier functions by vitamin A: implication...
Medeiros, Pedro Henrique Q. S. de; Pinto, Daniel V.; Almeida, Juliana Zani de; Rêgo, Juliana M. C.; Rodrigues, Francisco A. P.; Lima, Aldo Ângelo M.The micronutrient vitamin A refers to a group of compounds with pleiotropic effects on human health. These molecules can modulate biological functions, including development, vision, and regulation of the intestinal barrier. The consequences of vitamin A deficiency and supplementation in children from developing countries have been explored for several years. These children live in an environment that is highly...
Revisiting inbred mouse models to study the developing brain: the potential rol...
Oriá, Reinaldo B.; Malva, João O.; Foley, Patricia L.; Freitas, Raul S.; Bolick, David T.; Guerrant, Richard L.The life-long cumulative exposures (exposome) to environmental contaminants (even low-grade lead, mercury, arsenic etc.) and biological hazards (favoring enteric pathogens and altered “unhealthy” intestinal microbiota) alone or in combination are now being increasingly recognized to deleteriously influence the brain's development and potentially the way the brain copes with aging-related conditions, including n...
Genetic susceptibility to neurodegeneration in Amazon: apolipoprotein E genotyp...
Arrifano, Gabriela P. F.; Martín-Doimeadios, Rosa C. R.; Jiménez-Moreno, María; Fernández-Trujillo, Sergio; Augusto-Oliveira, MarcusHuman exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic susceptibility to mercury toxicity in the Amazon are scarce, and they tested a limited number o...
Docosanoids promote neurogenesis and angiogenesis, blood-brain barrier integrit...
Belayev, Ludmila; Hong, Sung-Ha; Menghani, Hemant; Marcell, Shawn J.; Obenaus, Andre; Freitas, Raul S.; Khoutorova, Larissa; Balaszczuk, VeronicaDocosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days...