2 documents found, page 1 of 1
Clinical characteristics and frequency of TLR4 polymorphisms in Brazilian patie...
Machado,Natalia Pereira; Nogueira,Eliana; Oseki,Karen; Ebbing,Pâmela Carolina Cruz; Origassa,Clarice Silvia Taemi; Mohovic,TatianeABSTRACT Objectives: Innate immunity is involved in the physiopathology of ankylosing spondylitis (AS), with the participation of Gram-negative bacteria, modulation of human leukocyte antigen (HLA) B27 and the involvement of pattern recognition receptors, such as Toll-like receptors (TLRs). The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and T...
Analysis of heparanase isoforms and cathepsin B in the plasma of patients with ...
Melo,Carina Mucciolo; Origassa,Clarice Silvia Taemi; Theodoro,Thérèse Rachell; Matos,Leandro Luongo; Miranda,Thaís Aguilar; Accardo,Camila MeloCONTEXT AND OBJECTIVE: Heparanase-1 degrades heparan sulfate and has been correlated with tumor progression. Although the isoform heparanase-2 has no catalytic activity, it seems to be important for modulating heparanase-1 activity. Cathepsin B is a proteinase involved in tumor metastasis. The aim of this study was to analyze heparanase isoform expression and cathepsin B activity in plasma samples from patients...