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Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Th...

Petit, Robert Gironés; Cano, Amanda; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Severino, Patrícia; Souto, Eliana B.

Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecula...


Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocul...

Sánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana Cristina

Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradab...


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