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Multidisciplinary integration in oncology treatment: synergy in radiology & rad...
Costa, Fernando M.; Saraiva, Daniela; Fonseca, Filipa; Casalta Lopes, João; Silva , Vítor; Monteiro, Armanda; Silva , Ana Catarina; Osório, LígiaBackground: The multidisciplinary impact between magnetic resonance imaging (MRI) and radiosurgery (SRS) has revolutionized cancer treatment, enhancing precision and patient outcomes. MRI provides superior soft tissue contrast in SRS where precise and effective high doses are delivered to small target volumes [1–3]. Image-fusion between MRI and Computed Tomography (CT) provides better visualization of the targe...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...