3 documents found, page 1 of 1
Prevalence of antibodies to a new histo-blood system: the FORS system
Jesus, C; Hesse, C; Rocha, C; Osório, N; Valado, A; Caseiro, A; Gabriel, A; Svensson, L; Moslemi, AR; Siba, WA; Srour, MA; Pereira, C; Tomaz, JIn 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman sa...
A nonribosomal peptide synthase gene driving virulence in Mycobacterium tubercu...
Bhatt, K; Machado, H; Osório, N; Sousa, J; Cardoso, F; Magalhães, C; Chen, B; Chen, M; Kim, J; Singh, A; Ferreira, C; Castro, A; Torrado, E; Jacobs, WNonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...
The troika host-pathogen-extrinsic factors in tuberculosis: Modulating inflamma...
Bastos, HN; Osório, N; Gagneux, S; Comas, I; Saraiva, MThe already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our under...