32 documents found, page 1 of 4

Development of polyurethane antimicrobial coatings by composition with phenolic...

Microorganisms can be found in almost all environments with high-touch surfaces being an important fomite for microbial growth. Considering the health issues associated to acquired infection from inanimate surfaces, as well as the raising hygienic concerns, the incorporation of antimicrobial compounds in high-touch surfaces emerges as an effective solution for biomedical and common daily applications. In this w...

Development of an ultraviolet-c irradiation room in a public Portuguese hospita...

Almost two years have passed since COVID-19 was officially declared a pandemic by the World Health Organization. However, it still holds a tight grasp on the entire human population. Several variants of concern, one after another, have spread throughout the world. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant may become the fastest spreading virus in history. Therefore, it is ...

Assessing textile antiviral properties

OmniSARS2: A Highly Sensitive and Specific RT-qPCR-Based COVID-19 Diagnostic Me...

Extensive transmission of SARS-CoV-2 during the COVID-19 pandemic allowed the generation of thousands of mutations within its genome. While several of these become rare, others largely increase in prevalence, potentially jeopardizing the sensitivity of PCR-based diagnostics. Taking advantage of SARS-CoV-2 genomic knowledge, we designed a one-step probe-based multiplex RT-qPCR (OmniSARS2) to simultaneously detec...

Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise an...

The already enormous burden caused by Mycobacterium tuberculosis and Human Immunodeficiency Virus type 1 (HIV-1) alone is aggravated by co-infection. Despite obvious differences in the rate of evolution comparing these two human pathogens, genetic diversity plays an important role in the success of both. The extreme evolutionary dynamics of HIV-1 is in the basis of a robust capacity to evade immune responses, t...

OmniSARS2: a highly sensitive and specific RT-qPCR-based COVID-19 diagnostic me...

Extensive transmission of SARS-CoV-2 during the COVID-19 pandemic allowed the generation of thousands of mutations within its genome. While several of these become rare, others largely increase in prevalence, potentially jeopardizing the sensitivity of PCR-based diagnostics. Taking advantage of SARS-CoV-2 genomic knowledge, we designed a one-step probe-based multiplex RT-qPCR (OmniSARS2) to simultaneously detec...

Nationwide study of drug resistance mutations in HIV-1 infected individuals und...

The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). Since Brazil presents the largest number of people living with HIV (PLWH) in South America we aimed at understanding the dynamics of DRM in this country. We analyzed a total of 20,226 HIV-1 sequences collected from PLWH undergoing ART between 2008–2017. Results show a mild decline of DRM over the yea...

Characterizing HIV-1 genetic subtypes and drug resistance mutations among child...

Human immunodeficiency virus (HIV) drug resistance (HIVDR) is widespread in sub-Saharan Africa. Children and pregnant women are particularly vulnerable, and laboratory testing capacity remains limited. We, therefore, used a cross-sectional design and convenience sampling to characterize HIV subtypes and resistance-associated mutations (RAMs) in these groups in Sierra Leone. In total, 96 children (age 2–9 years,...

The neglected contribution of streptomycin to the tuberculosis drug resistance ...

The airborne pathogen <i>Mycobacterium tuberculosis</i> is responsible for a present major public health problem worsened by the emergence of drug resistance. <i>M. tuberculosis</i> has acquired and developed streptomycin (STR) resistance mechanisms that have been maintained and transmitted in the population over the last decades. Indeed, STR resistant mutations are frequently identified across the main <i>M. t...

Investigação ao serviço da sociedade

[Excerto] A família Coronoviridae inclui uma panóplia de vírus compostos por envelope e RNA de cadeia simples que infetam aves e mamíferos (Payne, 2017). Existem pelo menos sete coronavírus humanos (HCoV), nomeadamente o HCoV-229E, o HCoV-OC43, o HCoV-NL63, o HCoV-HKU1, o coronavírus da síndrome respiratória aguda severa (SARS-CoV), o coronavírus da síndrome respiratória do Médio Oriente (MERS-CoV) e o mais rec...